KRAS inhibition in metastatic colorectal cancer: An update Review
| Authors: | Nusrat, M.; Yaeger, R. |
| Review Title: | KRAS inhibition in metastatic colorectal cancer: An update |
| Abstract: | About half of colorectal cancers harbor mutations in the KRAS gene. The presence of these mutations is associated with worse prognosis and, until now, the absence of matched targeted therapy options. In this review, we discuss clinical efforts to target KRAS in colorectal cancer from studies of downstream inhibitors to recent direct inhibitors of KRASG12C and other KRAS mutants. Early clinical trial data, however, suggest more limited activity for these novel inhibitors in colorectal cancer compared to other cancer types, and we discuss the role of receptor tyrosine kinase signaling and parallel signaling pathways in modulating response to these inhibitors. We also review the effect of KRAS mutations on the tumor-immune microenvironment and efforts to induce an immune response against these tumors. © 2022 Elsevier Ltd |
| Keywords: | signal transduction; gene mutation; review; nonhuman; gene targeting; cancer immunotherapy; genetic variability; antineoplastic activity; protein tyrosine kinase; immune response; cancer vaccine; drug response; cell therapy; k ras protein; protein inhibitor; tumor microenvironment; clinical trial (topic); metastatic colorectal cancer; metastasis inhibition; kras gene; cancer prognosis; human |
| Journal Title: | Current Opinion in Pharmacology |
| Volume: | 68 |
| ISSN: | 1471-4892 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2023-02-01 |
| Start Page: | 102343 |
| Language: | English |
| DOI: | 10.1016/j.coph.2022.102343 |
| PUBMED: | 36638742 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 February 2023 -- Source: Scopus |
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