Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy Journal Article


Authors: Maheshwari, N.; Marone, A.; Altoé, M.; Kim, S. H. K.; Bajakian, D. R.; Hielscher, A. H.
Article Title: Postintervention monitoring of peripheral arterial disease wound healing using dynamic vascular optical spectroscopy
Abstract: Significance: Due to the persistence of chronic wounds, a second surgical intervention is often necessary for patients with peripheral arterial disease (PAD) within a year of the first intervention. The dynamic vascular optical spectroscopy system (DVOS) may assist physicians in determining patient prognosis only a month after the first surgical intervention. Aim: We aim to assess the DVOS utility in characterizing wound healing in PAD patients after endovascular intervention. Approach: The DVOS used near-infrared light (670 < λ < 850 nm) to record hemodynamic response to a cuff inflation in 14 PAD patients with lower limb ulcers immediately before, immediately after, and at a first follow-up 3 to 4 weeks after intervention. Ankle-brachial index (ABI) and arterial duplex ultrasound (A-DUS) measurements were obtained when possible. Results: The total hemoglobin plateau time differed significantly between patients with ulcers that reduced in size (N = 9) and patients with ulcers that did not (N = 5) 3 to 4 weeks after intervention (p value < 0.001). Data correlated strongly (89% sensitivity, 100% specificity, and AUC . 0.96) with long-term wound healing. ABI and A-DUS measurements were not statistically associated with wound healing. Conclusions: This pilot study demonstrates the potential of the DVOS to aid physicians in giving accurate long-term wound healing prognoses 1 month after intervention. © 2022 The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Keywords: treatment outcome; retrospective studies; diagnostic imaging; retrospective study; wound healing; ischemia; pilot study; pilot projects; diagnosis; surgery; spectroscopy; diseases; ulcer; spectrum analysis; complication; infrared devices; revascularization; near infrared spectroscopy; peripheral occlusive artery disease; peripheral arterial disease; optical spectroscopy; humans; human; surgical interventions; near-infrared spectroscopy; dynamic optical spectroscopy; ankle-brachial indices; chronic wounds; post interventions; ultrasound measurement
Journal Title: Journal of Biomedical Optics
Volume: 27
Issue: 12
ISSN: 1083-3668
Publisher: SPIE  
Date Published: 2022-12-01
Start Page: 125002-1
End Page: 125002-14
Language: English
DOI: 10.1117/1.Jbo.27.12.125002
PUBMED: 36582192
PROVIDER: scopus
PMCID: PMC9789744
DOI/URL:
Notes: Article -- Export Date: 1 February 2023 -- Source: Scopus
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  1. Mirella Lorrainy Altoe
    6 Altoe