Small round blue cell sarcomas of bone: An update on classification, pathology and molecular profiling Review
| Authors: | Sumathi, V.; Hameed, M. |
| Review Title: | Small round blue cell sarcomas of bone: An update on classification, pathology and molecular profiling |
| Abstract: | Small round cell sarcomas of bone are extremely aggressive tumors, most often occurring in children and young adults. Recent genomic discoveries have contributed to the current classification of these tumors. The latest edition of the WHO Classification of Tumors of Soft Tissue and Bone identifies four subcategories each with distinct clinical features and prognostic outcome- Ewing sarcoma with ETS rearrangements and tumors with gene fusions involving EWSR1-non-ETS, CIC -rearranged tumors and sarcoma with BCOR genetic alterations. This chapter focuses on pathological findings of these entities with particular emphasis on the molecular characteristics to enable accurate classification and appropriate patient management. © 2022 |
| Keywords: | immunohistochemistry; osteosarcoma; gene mutation; overall survival; review; microscopy; molecular genetics; pathology; diagnostic imaging; ewing sarcoma; patient care; gene fusion; radiography; cancer classification; demographics; cancer prognosis; high throughput sequencing; bcor; human; rna sequencing; genetic profile; ewing-like sarcoma; cicrearranged sarcomas; ewsr1-non-ets; ewsr::nfatc2; small round blue cell sarcoma; srbct; small round blue cell sarcoma of bone |
| Journal Title: | Diagnostic Histopathology |
| Volume: | 28 |
| Issue: | 12 |
| ISSN: | 1756-2317 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-12-01 |
| Start Page: | 534 |
| End Page: | 540 |
| Language: | English |
| DOI: | 10.1016/j.mpdhp.2022.09.003 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 January 2023 -- Source: Scopus |
