Do all patients with primary refractory/first relapse of HL need autologous stem cell transplant? Review


Author: Moskowitz, A. J.
Review Title: Do all patients with primary refractory/first relapse of HL need autologous stem cell transplant?
Abstract: The standard approach to treatment of primary refractory/first relapse of classical Hodgkin lymphoma (cHL) is administration of second-line therapy (SLT) followed by consolidation with high-dose therapy and autologous hematopoietic cell transplantation (HDT/AHCT). Historically, this approach cured about 50% of patients. Due to improvements in supportive care, positron emission tomography-adaptive strategies, and incorporation of novel agents into SLT, contemporary studies show that about 75% of patients with primary refractory or first relapse of cHL can be cured. Recent studies evaluating incorporation of PD-1 blockade in SLT appear to show even further improvement in remission rates and bring into question whether an aggressive approach that includes HDT/AHCT is needed for everyone. To address this question, several ongoing studies are beginning to explore the possibility of avoiding or delaying HDT/AHCT for patients with primary refractory or first relapse of cHL. Copyright © 2022 by The American Society of Hematology.
Keywords: treatment outcome; antineoplastic agent; neoplasm recurrence, local; antineoplastic combined chemotherapy protocols; stem cell transplantation; hematopoietic stem cell transplantation; pathology; diagnostic imaging; hodgkin disease; tumor recurrence; transplantation, autologous; autotransplantation; humans; human
Journal Title: Hematology-American Society of Hematology Education Program
Volume: 2022
Issue: 1
ISSN: 1520-4391
Publisher: American Society of Hematology  
Date Published: 2022-12-09
Start Page: 699
End Page: 705
Language: English
DOI: 10.1182/hematology.2022000365
PUBMED: 36485099
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 3 January 2023 -- Source: Scopus
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  1. Alison Moskowitz
    355 Moskowitz