Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors Editorial
| Authors: | Schild, T.; Keshari, K. R. |
| Title: | Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors |
| Abstract: | Brain tumors are notoriously difficult to treat. Three recent Cancer Cell articles aim to uncover novel druggable targets in IDH mutant gliomas, diffuse midline gliomas, and medulloblastomas, respectively, and show that these brain tumor types shift their metabolism to become reliant on de novo pyrimidine synthesis. Copyright © 2022 Elsevier Inc. All rights reserved. |
| Keywords: | genetics; mutation; brain tumor; glioma; brain neoplasms; pathology; pyrimidines; pyrimidine derivative; isocitrate dehydrogenase; humans; human |
| Journal Title: | Cancer Cell |
| Volume: | 40 |
| Issue: | 12 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2022-12-12 |
| Start Page: | 1457 |
| End Page: | 1458 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2022.10.023 |
| PUBMED: | 36400017 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2023 -- Source: Scopus |
