Imaging cellular immunotherapies and immune cell biomarkers: From preclinical studies to patients Review
| Authors: | Volpe, A.; Adusumilli, P. S.; Schöder, H.; Ponomarev, V. |
| Review Title: | Imaging cellular immunotherapies and immune cell biomarkers: From preclinical studies to patients |
| Abstract: | Cellular immunotherapies have emerged as a successful therapeutic approach to fight a wide range of human diseases, including cancer. However, responses are limited to few patients and tumor types. An in-depth understanding of the complexity and dynamics of cellular immunotherapeutics, including what is behind their success and failure in a patient, the role of other immune cell types and molecular biomarkers in determining a response, is now paramount. As the cellular immunotherapy arsenal expands, whole-body non-invasive molecular imaging can shed a light on their in vivo fate and contribute to the reliable assessment of treatment outcome and prediction of therapeutic response. In this review, we outline the non-invasive strategies that can be tailored toward the molecular imaging of cellular immunotherapies and immune-related components, with a focus on those that have been extensively tested preclinically and are currently under clinical development or have already entered the clinical trial phase. We also provide a critical appraisal on the current role and consolidation of molecular imaging into clinical practice. |
| Keywords: | immunotherapy; tumors; mouse models; adaptive immunity; visualization; pet; antibody; expression; t-cells; receptors; responses; biodistribution; adoptive; in-vivo tracking; chimeric antigen |
| Journal Title: | Journal for ImmunoTherapy of Cancer |
| Volume: | 10 |
| Issue: | 9 |
| ISSN: | 2051-1426 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2022-09-01 |
| Start Page: | e004902 |
| Language: | English |
| ACCESSION: | WOS:000859832800006 |
| DOI: | 10.1136/jitc-2022-004902 |
| PROVIDER: | wos |
| PMCID: | PMC9511655 |
| PUBMED: | 36137649 |
| Notes: | Review -- Source: Wos |
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125Ponomarev -
554Schoder -
499Adusumilli -
11Volpe
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