Applications of nuclear-based imaging in gene and cell therapy: Probe considerations Review

   


Authors: Volpe, A.; Pillarsetty, N. V. K.; Lewis, J. S.; Ponomarev, V.
Review Title: Applications of nuclear-based imaging in gene and cell therapy: Probe considerations
Abstract: Several types of gene- and cell-based therapeutics are now emerging in the cancer immunotherapy, transplantation, and regenerative medicine landscapes. Radionuclear-based imaging can be used as a molecular imaging tool for repetitive and non-invasive visualization as well as in vivo monitoring of therapy success. In this review, we discuss the principles of nuclear-based imaging and provide a comprehensive overview of its application in gene and cell therapy. This review aims to inform investigators in the biomedical field as well as clinicians on the state of the art of nuclear imaging, from probe design to available radiopharmaceuticals and advances of direct (probe-based) and indirect (transgene-based) strategies in both preclinical and clinical settings. Notably, as the nuclear-based imaging toolbox is continuously expanding, it will be increasingly incorporated into the clinical setting where the distribution, targeting, and persistence of a new generation of therapeutics can be imaged and ultimately guide therapeutic decisions. This review aims to inform investigators and clinicians on the basic principles and new emerging radionuclear-based imaging approaches for the repetitive and non-invasive interrogation of gene and cell therapy and guide them in the advancement and clinical application of a new generation of therapeutics. © 2021 The Authors
Keywords: gene therapy; cell therapy; radiotracer; nuclear imaging
Journal Title: Molecular Therapy - Oncolytics
Volume: 20
ISSN: 2372-7705
Publisher: Cell Press  
Date Published: 2021-03-26
Start Page: 447
End Page: 458
Language: English
DOI: 10.1016/j.omto.2021.01.017
PROVIDER: scopus
PMCID: PMC7907215
PUBMED: 33718593
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101076620&doi=10.1016%2fj.omto.2021.01.017&partnerID=40&md5=7e6eea3d7b94b30ba74bf35c57c2fc41
Notes: Article -- Export Date: 1 April 2021 -- Source: Scopus
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MSK Authors
  1. Vladimir Ponomarev
    124 Ponomarev
  2. Nagavarakishore Pillarsetty
    134 Pillarsetty
  3. Jason S Lewis
    461 Lewis
  4. Alessia Volpe
    10 Volpe
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