Surgical management of pediatric salivary malignant tumors—A single-center cohort study Journal Article
| Authors: | Lopez, J.; Chen, Y. H.; Eagan, A.; Fitzgerald, C.; Woods, R.; Wong, R.; Shah, J.; Ganly, I. |
| Article Title: | Surgical management of pediatric salivary malignant tumors—A single-center cohort study |
| Abstract: | Background: The purpose of this study was to report incidence, clinicopathologic behavior, management, and outcome of pediatric patients treated surgically for salivary gland (SG) malignancies. Methods: Patients who underwent surgery for SG malignancies from 1985 to 2015 were identified. Clinical, pathological, treatment and outcomes data were collected. Disease-specific survival (DSS), recurrence-free survival (RFS), and overall survival (OS) were calculated using Kaplan–Meier method. Results: Twenty-eight pediatric patients were included. The most common histopathological types were mucoepidermoid (n = 18, 64.3%), acinic cell (n = 7, 25.0%), adenoid cystic (n = 2, 7.1%), and adenocarcinoma (n = 1, 3.6%). Surgical approach varied and ranged from superficial parotidectomy (n = 11, 39.3%) to partial maxillectomy (n = 6, 21.4%). Nine patients (32%) required postoperative radiotherapy. DSS, OS, and RFS probability at 5 years were 96.4%, 96.4%, and 89.3%, respectively. Conclusion: Pediatric SG malignancies are rare and have favorable outcome at 5 years. Larger, multi-institutional studies are required to better understand the natural history of these rare tumors. © 2022 Wiley Periodicals LLC. |
| Keywords: | adolescent; cancer survival; child; clinical article; human tissue; cancer surgery; retrospective studies; overall survival; histopathology; cancer recurrence; neck dissection; postoperative period; cancer patient; cancer radiotherapy; cancer staging; outcome assessment; cancer incidence; adenocarcinoma; cohort studies; cohort analysis; pathology; retrospective study; cancer center; salivary gland tumor; carcinoma, mucoepidermoid; salivary gland neoplasms; tertiary health care; salivary gland cancer; adenoid cystic carcinoma; acinar cell carcinoma; disease specific survival; maxilla resection; oral surgery; nerve graft; mandible resection; recurrence free survival; wide excision; nerve reconstruction; pediatric surgery; survival outcomes; superficial parotidectomy; mucoepidermoid tumor; humans; human; male; female; article; pediatric patient; pediatric salivary gland malignancies; facial nerve injury; total parotidectomy |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 126 |
| Issue: | 8 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2022-12-15 |
| Start Page: | 1389 |
| End Page: | 1395 |
| Language: | English |
| DOI: | 10.1002/jso.27063 |
| PUBMED: | 35969241 |
| PROVIDER: | scopus |
| PMCID: | PMC10251410 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2022 -- Source: Scopus |
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