Nanoscale nuclear environments, fine-scale 3D genome organization and transcription regulation Review
| Authors: | Li, J.; Pertsinidis, A. |
| Review Title: | Nanoscale nuclear environments, fine-scale 3D genome organization and transcription regulation |
| Abstract: | Decades of in vitro biochemical reconstitution, genetics and structural biology studies have established a vast knowledge base on the molecular mechanisms of chromatin regulation and transcription. A remaining challenge is to understand how these intricate biochemical systems operate in the context of the 3D genome organization and in the crowded and compartmentalized nuclear milieu. Here we review recent progress in this area based on high-resolution imaging approaches. © 2022 Elsevier Ltd |
| Keywords: | review; genetic transcription; genome analysis; human |
| Journal Title: | Current Opinion in Systems Biology |
| Volume: | 31 |
| ISSN: | 2452-3100 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-09-01 |
| Start Page: | 100436 |
| Language: | English |
| DOI: | 10.1016/j.coisb.2022.100436 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 December 2022 -- Source: Scopus |
