Nomogram for predicting malignancy in thyroid nodules using clinical, biochemical, ultrasonographic, and cytologic features Journal Article
| Authors: | Nixon, I. J.; Ganly, I.; Hann, L. E.; Lin, O.; Yu, C.; Brandt, S.; Shah, J. P.; Shaha, A.; Kattan, M. W.; Patel, S. G. |
| Article Title: | Nomogram for predicting malignancy in thyroid nodules using clinical, biochemical, ultrasonographic, and cytologic features |
| Abstract: | Background: Thyroid nodules often discovered incidentally and present a management problem particularly when investigations suggest atypical or suspicious cells. Prediction of the risk of malignancy within such a thyroid nodule is based on clinical, biochemical, ultrasonographic, and cytologic features. Our aim was to create a nomogram to predict accurately the chance of malignancy within a thyroid nodule. Methods: All patients with thyroid nodules who underwent ultrasonographic-guided fine needle aspiration and operative resection at our institution during 2007-2008 were identified. Clinical records, biochemical profiles, pathology reports, ultrasonographic images, and cytology slides were reviewed. A multivariate logistic regression was used to quantify the value of the variables in estimating the risk of malignancy. Results: The records of 158 patients with 190 nodules were reviewed. Eighteen nodules were excluded. The 8 variables with the greatest predictive value selected for the nomogram were biochemical (thyroid-stimulating hormone), ultrasonography (shape, echo texture, and vascularity), and cytology (nuclear grooves, pseudoinclusions, cellularity, and presence of colloid). The nomogram had an excellent predictive accuracy with a concordance index of 91%. Conclusion: We produced a nomogram that can quantify accurately the risk of malignancy in a thyroid nodule based on biochemical, ultrasonographic, and cytologic features. © 2010 Mosby, Inc. All rights reserved. |
| Keywords: | adult; human tissue; aged; major clinical study; diagnostic accuracy; chemical analysis; reproducibility of results; cytology; diagnosis, differential; calibration; vascularization; risk assessment; nomograms; echography; predictive value of tests; multivariate analysis; thyroid neoplasms; tertiary health care; aspiration biopsy; thyroid nodule; regression analysis; nomogram; thyrotropin; colloid; oxyphil cells |
| Journal Title: | Surgery |
| Volume: | 148 |
| Issue: | 6 |
| ISSN: | 0039-6060 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-12-01 |
| Start Page: | 1120 |
| End Page: | 1127 |
| Language: | English |
| DOI: | 10.1016/j.surg.2010.09.030 |
| PUBMED: | 21134542 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: SURGA" - "Source: Scopus" |
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