Non-invasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series Journal Article
| Authors: | Bang, A. S.; Monnier, J.; Harris, U.; Garfinkel, J.; Rubinstein, G.; Iftimia, N.; Pulitzer, M.; Murray, M.; Lacouture, M. E.; Jain, M. |
| Article Title: | Non-invasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series |
| Abstract: | Background: Cutaneous metastases (CM) diagnosis is clinically challenging, requiring an invasive biopsy for confirmation. A novel, RCM-OCT device combines the advantage of horizontal high-resolution reflectance confocal microscopy (RCM) images and vertical deeper optical coherence tomography (OCT) images to aid in non-invasive diagnosis of CM from breast cancers. Objective: Characterize CM from breast cancers using RCM-OCT device. Methods: Seven patients suffering from breast cancers with suspicious CM were consented and imaged with RCM-OCT device. CM features were defined by comparing with histopathology. Tumour depths were measured on OCT and on H&E-images and correlated using statistical analysis Pearson test. 3D-OCT images were reconstructed to enhance tumour visualization. Results: 6/7 lesions were CM from breast cancers, and one was vascular ectasia, on histopathology. CM appeared as greyish-darkish oval to round structures within the dermis on RCM and OCT-images. On RCM, individual tumour cells were seen, enabling identification of even small tumour foci; while, on OCT deeper tumours were detected. Inflammatory cells, dilated vessels and coarse collagen were identified in the dermis. Pearson correlation had an r2 of 0.38 and a significant P-value <0.004 for depth measurements. CM from breast cancers could be differentiated from ecstatic vessels on 3D-reconstructed OCT image. Limitation: Small sample size and lack of clinical mimickers. Conclusion: RCM-OCT can detect CM and has potential in aiding non-invasive diagnosis and management. © 2022 European Academy of Dermatology and Venereology. |
| Keywords: | clinical article; human tissue; histopathology; breast cancer; reflectance confocal microscopy; confocal microscopy; microscopy, confocal; skin neoplasms; in vivo study; pathology; diagnostic imaging; biopsy; inflammatory cell; vasodilatation; skin; skin tumor; tumor cell; skin metastasis; image reconstruction; correlational study; optical coherence tomography; procedures; three-dimensional imaging; tomography, optical coherence; humans; human; female; article |
| Journal Title: | Journal of the European Academy of Dermatology and Venereology |
| Volume: | 36 |
| Issue: | 11 |
| ISSN: | 0926-9959 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2022-11-01 |
| Start Page: | 2051 |
| End Page: | 2054 |
| Language: | English |
| DOI: | 10.1111/jdv.18344 |
| PUBMED: | 35729732 |
| PROVIDER: | scopus |
| PMCID: | PMC10337777 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2022 -- Source: Scopus |
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