Physiology of glymphatic solute transport and waste clearance from the brain Review

   


Authors: Zhao, L.; Tannenbaum, A.; Bakker, E. N. T. P.; Benveniste, H.
Review Title: Physiology of glymphatic solute transport and waste clearance from the brain
Abstract: This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics addressed include the biophysical characteristics of fluid and solute transport in the central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal fluid movement for brain waste clearance. We also discuss the current understanding of mechanisms underlying increased waste clearance during sleep.
Keywords: animal; animals; central nervous system; physiology; brain; cerebrospinal fluid; sleep; humans; human; solute transport; glymphatic system; glymphatic; waste clearance
Journal Title: Physiology
Volume: 37
Issue: 6
ISSN: 1548-9213
Publisher: American Physiological Society  
Date Published: 2022-11-01
Start Page: 349
End Page: 362
Language: English
DOI: 10.1152/physiol.00015.2022
PUBMED: 35881783
PROVIDER: scopus
PMCID: PMC9550574
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138449224&doi=10.1152%2fphysiol.00015.2022&partnerID=40&md5=580a5b2283f88cd570586be50ecf20ed
Notes: Review -- Export Date: 1 November 2022 -- Source: Scopus
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  1. Allen Tannenbaum
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