A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy Journal Article
| Authors: | Spurr, L. F.; Martinez, C. A.; Katipally, R. R.; Iyer, S. C.; Pugh, S. A.; Bridgewater, J. A.; Primrose, J. N.; Domingo, E.; Maughan, T. S.; D’Angelica, M. I.; Talamonti, M.; Posner, M. C.; Connell, P. P.; Weichselbaum, R. R.; Pitroda, S. P. |
| Article Title: | A proliferative subtype of colorectal liver metastases exhibits hypersensitivity to cytotoxic chemotherapy |
| Abstract: | Personalized treatment approaches for patients with limited liver metastases from colorectal cancer are critically needed. By leveraging three large, independent cohorts of patients with colorectal liver metastases (n = 336), we found that a proliferative subtype associated with elevated CIN70 scores is linked to immune exclusion, increased metastatic proclivity, and inferior overall survival in colorectal liver metastases; however, high CIN70 scores generate a therapeutic vulnerability to DNA-damaging therapies leading to improved treatment responses. We propose CIN70 as a candidate biomarker to personalize systemic treatment options for patients with metastatic colorectal cancer. These findings are potentially broadly applicable to other human cancers. © 2022, The Author(s). |
| Keywords: | treatment response; human cell; major clinical study; overall survival; exon; fluorouracil; cancer combination chemotherapy; cancer patient; topotecan; cell proliferation; progression free survival; carcinoembryonic antigen; analytic method; cohort analysis; cytotoxicity; cell population; tumor marker; irinotecan; image quality; dna damage response; hepatectomy; eosin; hematoxylin; cancer tissue; gene dosage; oxaliplatin; drug sensitivity; genetic code; aneuploidy; partial hepatectomy; complementary dna; rna degradation; antiproliferative activity; chromosome arm; clinical outcome; cancer prognosis; colorectal liver metastasis; human; article; rna sequencing; ic50; leave one out cross validation; cin70 score |
| Journal Title: | npj Precision Oncology |
| Volume: | 6 |
| ISSN: | 2397-768X |
| Publisher: | Springer Nature |
| Date Published: | 2022-10-14 |
| Start Page: | 72 |
| Language: | English |
| DOI: | 10.1038/s41698-022-00318-z |
| PROVIDER: | scopus |
| PMCID: | PMC9568565 |
| PUBMED: | 36241710 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2022 -- Source: Scopus |
