Antibody engineering for nuclear imaging and radioimmunotherapy Review
| Authors: | Rodriguez, C.; Delaney, S.; Sarrett, S. M.; Keinänen, O. M.; Zeglis, B. M. |
| Review Title: | Antibody engineering for nuclear imaging and radioimmunotherapy |
| Abstract: | Radiolabeled antibodies have become indispensable tools in nuclear medicine. However, the natural roles of antibodies within the immune system mean that they have several intrinsic limitations as a platform for radiopharmaceuticals. In recent years, the field has increasingly turned to antibody engineering to circumvent these issues while retaining the manifold benefits of the immunoglobulin framework. In this "Focus on Molecular Imaging" review, we cover recent advances in the application of antibody engineering to immunoPET, immunoSPECT, and radioimmunotherapy. Specifically, we address how antibody engineering has been used to improve radioimmunoconjugates on four fronts: optimizing pharmacokinetics, facilitating site-specific bioconjugation, modulating Fc interactions, and creating bispecific constructs. © 2022 by the Society of Nuclear Medicine and Molecular Imaging. |
| Keywords: | radiopharmaceuticals; molecular imaging; radiopharmaceutical agent; fc receptor; antibodies; radioimmunotherapy; pet; antibody; antibody engineering; antibody conjugate; immunoconjugates; antibody fragment; procedures |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 63 |
| Issue: | 9 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2022-09-01 |
| Start Page: | 1316 |
| End Page: | 1322 |
| Language: | English |
| DOI: | 10.2967/jnumed.122.263861 |
| PUBMED: | 35863894 |
| PROVIDER: | scopus |
| PMCID: | PMC9454464 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 November 2022 -- Source: Scopus |
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