Antibody-based molecular imaging Book Section
| Authors: | Tully, K. M.; Nagle, V. L.; Korsen, J. A.; Lewis, J. S. |
| Editors: | Ross, B. D.; Gambhir, S. S. |
| Article/Chapter Title: | Antibody-based molecular imaging |
| Abstract: | This chapter discusses the use of antibodies for molecular imaging with a focus on nuclear imaging to evaluate tumors at both an anatomical and molecular level. The chapter starts by discussing fluorescence-guided surgery (FGS), a technique in which fluorescently labeled antibodies have been incredibly useful for real-time intraoperative visualization of malignant versus healthy tissue. This technique is not only helpful for ensuring that all malignant tissue is resected, but also for minimalizing removal of healthy surrounding tissue. The chapter then describes the development of using antibodies in nuclear imaging, beginning with how radioisotopes are incorporated into the antibody structure. Examples of the various ways that immunoSPECT and immunoPET imaging can be used are discussed, including identifying lesions not seen using other imaging modalities; calculating radiation dosimetry for radioimmunotherapy; assessing biomarker levels in heterogeneous tumors; predicting patient responses to targeted therapies; and imaging the tumor immunologic microenvironment. The last section of this chapter describes the practice of pretargeting, which combines the superb specificity of antibodies with the shorter pharmacokinetics of small molecules in order to reduce radiation exposure during immunoSPECT or immunoPET imaging. © 2021 Elsevier Inc. All rights reserved. |
| Keywords: | immunotherapy; radioisotope; positron emission tomography (pet); theranostics; monoclonal antibody (mab); pretargeted pet imaging; single photon emission computed tomography (spect) |
| Book Title: | Molecular Imaging: Principles and Practice. 2nd ed |
| ISBN: | 978-0-12-816386-3 |
| Publisher: | Academic Press |
| Publication Place: | London, United Kingdom |
| Date Published: | 2021-01-01 |
| Start Page: | 547 |
| End Page: | 562 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-816386-3.00024-7 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter 30 in Volume 1 (ISBN: 978-0-12-820635-5), Part 3 of book section named "Chemistry of Molecular Imaging" -- Export Date: 1 June 2022 -- Source: Scopus |
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