Impact of TP53 mutations in triple negative breast cancer Journal Article
| Authors: | Mitri, Z. I.; Abuhadra, N.; Goodyear, S. M.; Hobbs, E. A.; Kaempf, A.; Thompson, A. M.; Moulder, S. L. |
| Article Title: | Impact of TP53 mutations in triple negative breast cancer |
| Abstract: | Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens. © 2022, The Author(s). |
| Keywords: | adult; controlled study; middle aged; gene mutation; major clinical study; overall survival; missense mutation; postoperative period; outcome assessment; follow up; clinical assessment; cohort analysis; pathology; protein p53; neoadjuvant chemotherapy; dna binding; recurrence free survival; triple negative breast cancer; clinical outcome; human; female; article; prognostic assessment |
| Journal Title: | npj Precision Oncology |
| Volume: | 6 |
| ISSN: | 2397-768X |
| Publisher: | Springer Nature |
| Date Published: | 2022-09-09 |
| Start Page: | 64 |
| Language: | English |
| DOI: | 10.1038/s41698-022-00303-6 |
| PROVIDER: | scopus |
| PMCID: | PMC9463132 |
| PUBMED: | 36085319 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2022 -- Source: Scopus |
