Are acinic cell carcinomas of the breast and salivary glands distinct diseases? Journal Article

   


Authors: Piscuoglio, S.; Hodi, Z.; Katabi, N.; Guerini Rocco, E.; Macedo, G. S.; Ng, C. K. Y.; Edelweiss, M.; De Mattos-Arruda, L.; Wen, H. Y.; Rakha, E. A.; Ellis, I. O.; Rubin, B. P.; Weigelt, B.; Reis-Filho, J. S.
Article Title: Are acinic cell carcinomas of the breast and salivary glands distinct diseases?
Abstract: Aims: Acinic cell carcinomas (AcCC) of the breast have been reported to constitute the breast counterpart of salivary gland AcCCs, based on the similarities of their histological and immunohistochemical features. Breast AcCC is a vanishingly rare form of triple-negative breast cancer (TNBC). Recent studies have demonstrated that in TNBCs, the two driver genes most frequently mutated are TP53 (82%) and PIK3CA (10%). We sought to define whether breast AcCCs would harbour TP53 and PIK3CA somatic mutations, and if so, whether these would be present in salivary gland AcCCs. Methods and results: Sanger sequencing of the entire coding region of TP53 and of PIK3CA hotspot mutation sites of 10 breast and 20 salivary gland microdissected AcCCs revealed eight TP53 (80%) and one PIK3CA (10%) somatic mutations in breast AcCCs. No somatic mutations affecting these genes were found in the 20 salivary gland AcCCs analysed. Conclusions: Our findings demonstrate that breast AcCCs display TP53 and PIK3CA mutations at frequencies similar to those of common types of TNBCs, whereas these genes appear not to be altered in salivary gland AcCCs, suggesting that despite their similar histological appearances, AcCCs of the breast and salivary glands probably constitute unrelated diseases. © 2015 John Wiley & Sons Ltd.
Keywords: immunohistochemistry; adult; clinical article; human tissue; aged; gene mutation; gene sequence; somatic mutation; histopathology; breast; gene frequency; oncogene; tumor suppressor gene; salivary gland; acinar cell carcinoma; salivary gland carcinoma; pik3ca gene; sequencing; triple negative breast cancer; tp53; pik3ca; human; male; female; priority journal; article; acinic cell carcinoma of the breast; acinic cell carcinoma of the salivary gland
Journal Title: Histopathology
Volume: 67
Issue: 4
ISSN: 0309-0167
Publisher: Wiley Blackwell  
Date Published: 2015-10-01
Start Page: 529
End Page: 537
Language: English
DOI: 10.1111/his.12673
PROVIDER: scopus
PUBMED: 25688711
PMCID: PMC5006393
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84941599966&partnerID=40&md5=d14f007cc87768ecccb036a45bce3d51
Notes: Export Date: 2 October 2015 -- Source: Scopus
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MSK Authors
  1. Nora Katabi
    303 Katabi
  2. Hannah Yong Wen
    301 Wen
  3. Marcia Edelweiss
    104 Edelweiss
  4. Britta Weigelt
    632 Weigelt
  5. Jorge Sergio Reis-Filho
    639 Reis-Filho
  6. Kiu Yan Charlotte Ng
    155 Ng
  7. Salvatore Piscuoglio
    130 Piscuoglio
  8. Elena Guerini Rocco
    32 Guerini Rocco
  9. Leticia De Mattos Arruda
    15 De Mattos Arruda
  10. Gabriel De Souza Macedo
    19 De Souza Macedo
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