Fifty years of progress in surgical oncology: Melanoma Review
| Authors: | Coit, D. G.; Ariyan, C. E. |
| Review Title: | Fifty years of progress in surgical oncology: Melanoma |
| Abstract: | This paper outlines the scientific and clinical advances in the treatment of melanoma over the past 50 years. Among the highlights of progress, the dominant themes include evidence-based reduction in the extent and morbidity of surgical procedures in patients with local or regional melanoma without compromising end results, and the introduction of effective systemic therapy, specifically targeted therapy matched to patients based on specific tumor mutations, and immune checkpoint blockade. Management of advanced disease has also changed dramatically, due to improved understanding of the genomic variability of the disease as well as continuing improvements in imaging. © 2022 Wiley Periodicals LLC. |
| Keywords: | immunohistochemistry; cancer survival; treatment response; cancer surgery; gene mutation; overall survival; genetics; advanced cancer; systemic therapy; cancer adjuvant therapy; neoadjuvant therapy; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; lymph node metastasis; lymph node dissection; sentinel lymph node biopsy; cytotoxic t lymphocyte antigen 4 antibody; melanoma; computer assisted tomography; gene expression profiling; skin neoplasms; morbidity; genetic variability; cancer therapy; distant metastasis; skin tumor; immunotherapy; fluorodeoxyglucose f 18; cytotoxic t lymphocyte antigen 4; management; b raf kinase; regional metastasis; recurrence free survival; programmed death 1 ligand 1; surgical margin; molecularly targeted therapy; wide excision; metastasis resection; procedures; surgical oncology; immune checkpoint inhibitor; humans; human; article; gilvetmab; tumor mutational burden; chimeric antigen receptor t-cell immunotherapy |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 126 |
| Issue: | 5 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2022-10-01 |
| Start Page: | 888 |
| End Page: | 895 |
| Language: | English |
| DOI: | 10.1002/jso.27081 |
| PUBMED: | 36087090 |
| PROVIDER: | scopus |
| PMCID: | PMC9473298 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2022 -- Source: Scopus |
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