Perfecting antigen prediction Editorial
| Authors: | Hoyos, D.; Greenbaum, B. D. |
| Title: | Perfecting antigen prediction |
| Abstract: | Advances in genomics and precision measurement have continued to demonstrate the importance of the immune system across many disease types. At the heart of many emerging approaches to leverage these insights for precision immunotherapies is the computational antigen prediction problem. We propose a threefold approach to improving antigen predictions: further defining the geometry of the antigen landscape, incorporating the coupling of antigen recognition to other cellular processes, and diversifying the training sets used for models that predict immunogenicity. © 2022 Hoyos and Greenbaum. |
| Keywords: | protein expression; gene mutation; note; information processing; prediction; antigen; immunotherapy; antigens; immunogenicity; antigen recognition; genomics; dna sequence; microenvironment; computer model; vaccine development; rna sequence; molecular pathology; machine learning; ecological niche; predictive model; rna vaccine |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 219 |
| Issue: | 9 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2022-09-05 |
| Start Page: | e20220846 |
| Language: | English |
| DOI: | 10.1084/jem.20220846 |
| PUBMED: | 35972475 |
| PROVIDER: | scopus |
| PMCID: | PMC9386507 |
| DOI/URL: | |
| Notes: | Note -- Export Date: 3 October 2022 -- Source: Scopus |
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