Real-world management of targeted therapies in chronic lymphocytic leukemia Review
| Authors: | Weis, T. M.; Gutierrez, J.; Kabel, C. C.; King, A. C.; Daley, R. J.; Stump, S. E. |
| Review Title: | Real-world management of targeted therapies in chronic lymphocytic leukemia |
| Abstract: | The advent of novel targeted therapies, including B-cell receptor (BCR) pathway and B-cell lymphoma 2 (BCL2) inhibitors, has substantially changed the treatment paradigm for chronic lymphocytic leukemia (CLL). Although targeted therapies have improved outcomes compared to traditional chemoimmunotherapy in the front-line and relapsed or refractory settings, they are associated with resistance mutations and suboptimal outcomes in certain high-risk patients. Additionally, targeted therapies are associated with drug interactions and unique adverse effect profiles which can be challenging for patients and clinicians to manage. Ongoing studies continue to address questions regarding optimal sequencing of therapies, the role of treatment combinations, and the efficacy of next-generation novel agents. This review provides a comprehensive overview regarding the clinical management of targeted therapies for CLL and applies current literature to clinical practice. |
| Keywords: | drug therapy, combination; enzyme inhibitors; drug interactions; receptors, cell surface; antineoplastic agents -- therapeutic use; medical practice, evidence-based; research, medical; b lymphocytes; leukemia, lymphocytic, chronic -- drug therapy; protein-tyrosine kinases -- antagonists and inhibitors |
| Journal Title: | Journal of Oncology Pharmacy Practice |
| Volume: | 28 |
| Issue: | 6 |
| ISSN: | 1078-1552 |
| Publisher: | Sage Publications Ltd. |
| Date Published: | 2022-09-01 |
| Start Page: | 1411 |
| End Page: | 1433 |
| Language: | English |
| DOI: | 10.1177/10781552221090869 |
| PROVIDER: | EBSCOhost |
| PROVIDER: | cinahl |
| PUBMED: | 35350909 |
| DOI/URL: | |
| Notes: | Accession Number: 158513184 -- Entry Date: 20220824 -- Revision Date: 20220824 -- Publication Type: Article; review; tables/charts -- Journal Subset: Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Peer Reviewed; USA -- NLM UID: 9511372. -- Source: Cinahl |
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