Points to consider regarding risk-reducing mastectomy in high-, moderate-, and low-penetrance gene carriers Review
| Authors: | Corso, G.; Robson, M. E.; Sacchini, V. |
| Review Title: | Points to consider regarding risk-reducing mastectomy in high-, moderate-, and low-penetrance gene carriers |
| Abstract: | Risk-reducing mastectomy is considered a safe and effective surgical procedure in high-risk individuals with BRCA1/2 germline mutations. Multigene panels identify women with alterations in breast cancer susceptibility genes other than BRCA1/2. International guidelines classify these genes as high-, moderate-, and low-penetrance based on their associated relative risk for breast cancer. Classification of specific genes is not always concordant among guidelines, and the indications for risk-reducing mastectomy are not defined. In this opinion paper, we review some considerations to clarify these controversial points. © 2022, Society of Surgical Oncology. |
| Keywords: | cancer surgery; genetics; mutation; cancer risk; cancer susceptibility; genetic predisposition to disease; breast cancer; mastectomy; practice guideline; breast neoplasms; brca1 protein; brca2 protein; protein p53; germ line; tumor suppressor gene; genes, brca1; genes, brca2; genetic susceptibility; breast tumor; medical society; risk reduction; tumor gene; genetic predisposition; penetrance; prophylactic mastectomy; protein kinase lkb1; procedures; humans; human; female; article; fizzy related protein; partner and localizer of brca2 |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 29 |
| Issue: | 9 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2022-09-01 |
| Start Page: | 5821 |
| End Page: | 5825 |
| Language: | English |
| DOI: | 10.1245/s10434-022-11913-6 |
| PUBMED: | 35604619 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 September 2022 -- Source: Scopus |
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