BRCA1/2 test results impact risk management attitudes, intentions, and uptake Journal Article
| Authors: | O'Neill, S. C.; Valdimarsdottir, H. B.; Demarco, T. A.; Peshkin, B. N.; Graves, K. D.; Brown, K.; Hurley, K. E.; Isaacs, C.; Hecker, S.; Schwartz, M. D. |
| Article Title: | BRCA1/2 test results impact risk management attitudes, intentions, and uptake |
| Abstract: | Women who receive positive or uninformative BRCA1/2 test results face a number of decisions about how to manage their cancer risk. The purpose of this study was to prospectively examine the effect of receiving a positive versus uninformative BRCA1/2 genetic test result on the perceived pros and cons of risk-reducing mastectomy (RRM) and risk-reducing oophorectomy (RRO) and breast cancer screening. We further examined how perceived pros and cons of surgery predict intention for and uptake of surgery. 308 women (146 positive, 162 uninformative) were included in RRM and breast cancer screening analyses. 276 women were included in RRO analyses. Participants completed questionnaires at pre-disclosure baseline and 1-, 6-, and 12-months post-disclosure. We used linear multiple regression to assess whether test result contributed to change in pros and cons and logistic regression to predict intentions and surgery uptake. Receipt of a positive BRCA1/2 test result predicted stronger pros for RRM and RRO (P < 0.001), but not perceived cons of RRM and RRO. Pros of surgery predicted RRM and RRO intentions in carriers and RRO intentions in uninformatives. Cons predicted RRM intentions in carriers. Pros and cons predicted carriers' RRO uptake in the year after testing (P < 0.001). Receipt of BRCA1/2 mutation test results impacts how carriers see the positive aspects of RRO and RRM and their surgical intentions. Both the positive and negative aspects predict uptake of surgery. © 2010 Springer Science+Business Media, LLC. |
| Keywords: | adult; controlled study; middle aged; gene mutation; major clinical study; mutation; risk benefit analysis; united states; prospective studies; genetic analysis; ovarian neoplasms; linear models; ovary cancer; breast cancer; mastectomy; logistic models; ovariectomy; odds ratio; risk factors; health behavior; randomized controlled trials as topic; cancer screening; mass screening; breast neoplasms; brca1 protein; brca2 protein; prediction; time factors; risk assessment; questionnaires; questionnaire; mammography; screening; predictive value of tests; intention; interpersonal communication; patient decision making; dna mutational analysis; health knowledge, attitudes, practice; risk reduction; patient attitude; choice behavior; patient acceptance of health care; genetic testing; breast biopsy; risk management; prophylactic mastectomy; brca mutation; cons; prophylactic oophorectomy; pros |
| Journal Title: | Breast Cancer Research and Treatment |
| Volume: | 124 |
| Issue: | 3 |
| ISSN: | 0167-6806 |
| Publisher: | Springer |
| Date Published: | 2010-12-01 |
| Start Page: | 755 |
| End Page: | 764 |
| Language: | English |
| DOI: | 10.1007/s10549-010-0881-4 |
| PUBMED: | 20383578 |
| PROVIDER: | scopus |
| PMCID: | PMC3039480 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: BCTRD" - "Source: Scopus" |
