Cytomorphology of NUTM1-rearranged sarcoma involving pleural fluid Journal Article
| Authors: | Chen, L.; Larsen, B.; Dermawan, J. K.; Zarka, M. A. |
| Article Title: | Cytomorphology of NUTM1-rearranged sarcoma involving pleural fluid |
| Abstract: | We describe an exceedingly rare cytology case of a NUTM1-rearranged sarcoma involving pleural fluid. A 48-year-old female presented with progressive abdominal pain. Computed tomography (CT) scan of the abdomen revealed a 5.6 cm soft tissue mass in the right hemi-abdomen. Needle core biopsy of the mass showed a small round cell tumor. Extensive work-up including next generation sequencing (NGS) demonstrated a NUTM1:MXI1 rearranged sarcoma. The patient was first treated with ifosfamide, carboplatin, and etoposide (ICE) chemotherapy. She responded initially and then progressed with multiple masses in the abdomen and pleural effusion. The cytology of the pleural effusion showed clusters and single small round blue cells. Some of them displayed rhabdoid morphology. Immunostains of NUT antibody on cell block demonstrated strong positivity of NUT. NUTM1-rearranged sarcoma is an emerging class of mesenchymal neoplasm and the cytomorphology of this neoplasm in liquid-based cytology (LBC) is yet to be described. We herein reported the first cytology case of NUTM1-rearranged sarcoma in pleural fluid. © 2022 Wiley Periodicals LLC. |
| Keywords: | immunohistochemistry; adult; clinical article; human tissue; middle aged; oncoprotein; genetics; histopathology; case report; carboplatin; computer assisted tomography; multiple cycle treatment; tumor volume; nuclear protein; etoposide; peritoneal biopsy; transcription factor; pathology; tumor marker; ifosfamide; transcription factors; nuclear proteins; abdominal pain; sarcoma; needle biopsy; drug response; oncogene proteins, fusion; pleura effusion; pleura fluid; abdominal mass; romidepsin; soft tissue neoplasms; soft tissue tumor; cytodiagnosis; hospice care; liquid-based cytology; pleural effusion; general condition deterioration; high throughput sequencing; humans; human; female; article; biomarkers, tumor; nutm1-rearranged sarcoma; pleural fluid cytology; nutm1 rearranged sarcoma |
| Journal Title: | Diagnostic Cytopathology |
| Volume: | 50 |
| Issue: | 9 |
| ISSN: | 8755-1039 |
| Publisher: | Wiley Liss |
| Date Published: | 2022-09-01 |
| Start Page: | E244 |
| End Page: | E247 |
| Language: | English |
| DOI: | 10.1002/dc.24968 |
| PUBMED: | 35441831 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 September 2022 -- Source: Scopus |
