Cellular and molecular mechanisms of plasticity in cancer Review
| Authors: | Torborg, S. R.; Li, Z.; Chan, J. E.; Tammela, T. |
| Review Title: | Cellular and molecular mechanisms of plasticity in cancer |
| Abstract: | Cancer cells are plastic – they can assume a wide range of distinct phenotypes. Plasticity is integral to cancer initiation and progression, as well as to the emergence and maintenance of intratumoral heterogeneity. Furthermore, plastic cells can rapidly adapt to and evade therapy, which poses a challenge for effective cancer treatment. As such, targeting plasticity in cancer holds tremendous promise. Yet, the principles governing plasticity in cancer cells remain poorly understood. Here, we provide an overview of the fundamental molecular and cellular mechanisms that underlie plasticity in cancer and in other biological contexts, including development and regeneration. We propose a key role for high-plasticity cell states (HPCSs) as crucial nodes for cell state transitions and enablers of intra-tumoral heterogeneity. © 2022 Elsevier Inc. |
| Keywords: | review; cancer therapy; regeneration; cancer cell; conformational transition; differentiation; plasticity; intratumoral heterogeneity; human; tumor evolution; cell state transition |
| Journal Title: | Trends in Cancer |
| Volume: | 8 |
| Issue: | 9 |
| ISSN: | 2405-8025 |
| Publisher: | Cell Press |
| Date Published: | 2022-09-01 |
| Start Page: | 735 |
| End Page: | 746 |
| Language: | English |
| DOI: | 10.1016/j.trecan.2022.04.007 |
| PUBMED: | 35618573 |
| PROVIDER: | scopus |
| PMCID: | PMC9388572 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 September 2022 -- Source: Scopus |
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