Avoiding toxicity with lung radiation therapy: An IASLC perspective Review
| Authors: | Bucknell, N. W.; Belderbos, J.; Palma, D. A.; Iyengar, P.; Samson, P.; Chua, K.; Gomez, D.; McDonald, F.; Louie, A. V.; Faivre-Finn, C.; Hanna, G. G.; Siva, S.; on behalf of the International Association for the Study of Lung Cancer Advanced Radiation Technology Committee |
| Review Title: | Avoiding toxicity with lung radiation therapy: An IASLC perspective |
| Abstract: | Toxicity concerns from thoracic radiation therapy in the treatment of lung cancers have changed substantially over the past few decades. Survival in the treatment of lung cancer has markedly improved and the introduction of advanced radiation and imaging techniques to treatment planning and delivery has made reducing toxicity possible. Phase 3 dose-escalation trials have revealed that excess dose to critical organs within the thorax can negatively impact overall survival. We summarize the existing literature on the known toxicities of thoracic radiation therapy, summarize the technological advances that have made toxicity reduction possible, and provide an overview of emerging technologies and biomarkers that are being evaluated to assess future toxicity reductions. © 2022 |
| Keywords: | carcinoma, non-small-cell lung; lung neoplasms; lung tumor; lung; stereotactic body radiation therapy; small cell lung cancer; non small cell lung cancer; radiation toxicity; humans; human; early-stage lung cancer; non–small cell lung cancer; locally advanced lung cancer |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 17 |
| Issue: | 8 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-08-01 |
| Start Page: | 961 |
| End Page: | 973 |
| Language: | English |
| DOI: | 10.1016/j.jtho.2022.05.003 |
| PUBMED: | 35649502 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 September 2022 -- Source: Scopus |
