Myeloma precursor disease (MGUS) among rescue and recovery workers exposed to the World Trade Center disaster Journal Article

   


Authors: Zeig-Owens, R.; Goldfarb, D. G.; Luft, B. J.; Yang, X.; Murata, K.; Ramanathan, L.; Thoren, K.; Doddi, S.; Shah, U. A.; Mueller, A. K.; Hall, C. B.; Giricz, O.; Verma, A.; Prezant, D. J.; Landgren, O.
Article Title: Myeloma precursor disease (MGUS) among rescue and recovery workers exposed to the World Trade Center disaster
Abstract: An elevated risk of myeloma precursor disease, monoclonal gammopathy of undetermined significance (MGUS), was identified among Fire Department of the City of New York (FDNY) World Trade Center (WTC)-exposed firefighters. Further investigation was needed to determine if these findings were reproducible in a more heterogeneous WTC-exposed rescue/recovery workers cohort, the Stony Brook University-General Responder Cohort GRC (SBU-GRC). MGUS risk was compared between the cohorts and to published general population estimates from Olmsted County, MN, USA. In this observational seroprevalence study, odds ratios (OR) and age-standardized risk ratios (RR) of MGUS (M-spike and light-chain-MGUS combined), M-spike, and light-chain-MGUS were estimated using logistic regression. Age-standardized prevalences were calculated for white males aged 50-79; RRs were estimated by comparing risk in the WTC-exposed cohort with the Olmsted County screened cohort. SBU-GRC had elevated odds of MGUS compared with FDNY (OR = 1.38; 95%CI = 1.00-1.89). The age-standardized prevalence of MGUS was 9.0/100 persons (95%CI = 7.5-10.6), over two-fold higher than the general population (RR = 2.08; 95%CI = 1.72-2.51); the age-standardized prevalence of light-chain-MGUS was 3.5-fold higher (RR = 3.54; 95%CI = 2.52-4.97). This study adds to mounting evidence supporting an association between WTC/environmental exposures and MGUS among rescue/recovery workers. Access to MGUS screenings for the entire WTC-exposed cohort could allow for treatment interventions that improve survival. © 2022. The Author(s).
Journal Title: Blood Cancer Journal
Volume: 12
Issue: 8
ISSN: 2044-5385
Publisher: Nature Publishing Group  
Date Published: 2022-08-22
Start Page: 120
Language: English
DOI: 10.1038/s41408-022-00709-2
PUBMED: 35995768
PROVIDER: scopus
PMCID: PMC9395354
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85136215902&doi=10.1038%2fs41408-022-00709-2&partnerID=40&md5=ea0d2289ca90867b088708214ac3d394
Notes: Article -- Export Date: 1 September 2022 -- Source: Scopus
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MSK Authors
  1. Kazunori Murata
    33 Murata
  2. Lakshmi Vulimiri Ramanathan
    77 Ramanathan
  3. Urvi A Shah
    187 Shah
  4. Sital Doddi
    10 Doddi
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