A pilot study of micro-CT-based whole tissue imaging (WTI) on endoscopic submucosal dissection (ESD) specimens Journal Article


Authors: Sakamoto, H.; Nishimura, M.; Teplov, A.; Leung, G.; Ntiamoah, P.; Cesmecioglu, E.; Kawata, N.; Ohnishi, T.; Kareem, I.; Shia, J.; Yagi, Y.
Article Title: A pilot study of micro-CT-based whole tissue imaging (WTI) on endoscopic submucosal dissection (ESD) specimens
Abstract: Endoscopic submucosal dissection can remove large superficial gastrointestinal lesions in en bloc. A detailed pathological evaluation of the resected specimen is required to assess the risk of recurrence after treatment. However, the current method of sectioning specimens to a thickness of a few millimeters does not provide information between the sections that are lost during the preparation. In this study, we have produced three-dimensional images of the entire dissected lesion for nine samples by using micro-CT imaging system. Although it was difficult to diagnose histological type on micro-CT images, it successfully evaluates the extent of the lesion and its surgical margins. Micro-CT images can depict sites that cannot be observed by the conventional pathological diagnostic process, suggesting that it may be useful to use in a complementary manner.
Keywords: resection; computed tomography; cancer
Journal Title: Scientific Reports
Volume: 12
ISSN: 2045-2322
Publisher: Nature Publishing Group  
Date Published: 2022-06-14
Start Page: 9889
Language: English
ACCESSION: WOS:000811293500060
DOI: 10.1038/s41598-022-13907-6
PROVIDER: wos
PMCID: PMC9198046
PUBMED: 35701447
Notes: Author Kareem Ibrahim's first name and last name are swapped in the PDF and publisher record -- Source: Wos
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Citation Impact
MSK Authors
  1. Jinru Shia
    626 Shia
  2. Alexei Teplov
    28 Teplov
  3. Yukako Yagi
    53 Yagi
  4. Kareem Salah Ibrahim
    20 Ibrahim
  5. Noboru Kawata
    9 Kawata
  6. Takashi Ohnishi
    11 Ohnishi
  7. Galen Leung
    2 Leung