Visualization of experimental lung and bone metastases in live nude mice by X-ray micro-computed tomography Journal Article
| Authors: | Li, X. F. ; Zanzonico, P.; Ling, C. C.; O'Donoghue, J. |
| Article Title: | Visualization of experimental lung and bone metastases in live nude mice by X-ray micro-computed tomography |
| Abstract: | The objective of this study was to evaluate the utility of micro-computed tomography (micro-CT) for the detection and monitoring of experimental lung and bone metastases in nude mice. Whole body micro-CT scans were performed in lung or bone metastasis-bearing nude mice under deep anesthesia. The volumes of individual lung metastases were estimated by micro-CT, and compared to direct measurements on excised tumors. The two data sets were highly correlated (p<0.0001). The smallest lung tumor detected was 0.85 mm in diameter. The progression of metastatic lung disease, including tumor growth and the development of pleural effusion, was visualized by serial micro-CT scans in live mice. In addition, multiple bony metastases, with both osteolytic and osteoblastic features, were successfully detected by micro-CT. Bone lesions identified by micro-CT were confirmed as metastases by histopathological examination. Micro-CT may be used as an accurate, noninvasive tool to detect and monitor experimental bone and lung metastases in intact live nude mice. ©Adenine Press (2006). |
| Keywords: | controlled study; bone neoplasms; osteolysis; histopathology; review; nonhuman; bone metastasis; neoplasm staging; diagnostic accuracy; adenocarcinoma; mouse; animals; mice; animal tissue; computer assisted tomography; tumor volume; lung neoplasms; animal experiment; animal model; tomography, x-ray computed; lung metastasis; nude mouse; mice, nude; diagnostic value; contrast enhancement; device; data analysis; contrast medium; pleura effusion; micro-computed tomography; tumor growth; image reconstruction; osteoblast; anesthesia; x-ray; microradiography |
| Journal Title: | Technology in Cancer Research & Treatment |
| Volume: | 5 |
| Issue: | 2 |
| ISSN: | 1533-0346 |
| Publisher: | Sage Publications, Inc. |
| Date Published: | 2006-04-01 |
| Start Page: | 147 |
| End Page: | 155 |
| Language: | English |
| PUBMED: | 16551134 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 4 June 2012" - "CODEN: TCRTB" - "Source: Scopus" |
