Visualization of experimental lung and bone metastases in live nude mice by X-ray micro-computed tomography Journal Article


Authors: Li, X. F. ; Zanzonico, P.; Ling, C. C.; O'Donoghue, J.
Article Title: Visualization of experimental lung and bone metastases in live nude mice by X-ray micro-computed tomography
Abstract: The objective of this study was to evaluate the utility of micro-computed tomography (micro-CT) for the detection and monitoring of experimental lung and bone metastases in nude mice. Whole body micro-CT scans were performed in lung or bone metastasis-bearing nude mice under deep anesthesia. The volumes of individual lung metastases were estimated by micro-CT, and compared to direct measurements on excised tumors. The two data sets were highly correlated (p<0.0001). The smallest lung tumor detected was 0.85 mm in diameter. The progression of metastatic lung disease, including tumor growth and the development of pleural effusion, was visualized by serial micro-CT scans in live mice. In addition, multiple bony metastases, with both osteolytic and osteoblastic features, were successfully detected by micro-CT. Bone lesions identified by micro-CT were confirmed as metastases by histopathological examination. Micro-CT may be used as an accurate, noninvasive tool to detect and monitor experimental bone and lung metastases in intact live nude mice. ©Adenine Press (2006).
Keywords: controlled study; bone neoplasms; osteolysis; histopathology; review; nonhuman; bone metastasis; neoplasm staging; diagnostic accuracy; adenocarcinoma; mouse; animals; mice; animal tissue; computer assisted tomography; tumor volume; lung neoplasms; animal experiment; animal model; tomography, x-ray computed; lung metastasis; nude mouse; mice, nude; diagnostic value; contrast enhancement; device; data analysis; contrast medium; pleura effusion; micro-computed tomography; tumor growth; image reconstruction; osteoblast; anesthesia; x-ray; microradiography
Journal Title: Technology in Cancer Research & Treatment
Volume: 5
Issue: 2
ISSN: 1533-0346
Publisher: Sage Publications, Inc.  
Date Published: 2006-04-01
Start Page: 147
End Page: 155
Language: English
PUBMED: 16551134
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 19" - "Export Date: 4 June 2012" - "CODEN: TCRTB" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Xiao-Feng Li
    11 Li
  2. Pat B Zanzonico
    315 Zanzonico
  3. C Clifton Ling
    331 Ling