Machine learning radiomics can predict early liver recurrence after resection of intrahepatic cholangiocarcinoma Journal Article


Authors: Jolissaint, J. S.; Wang, T.; Soares, K. C.; Chou, J. F.; Gönen, M.; Pak, L. M.; Boerner, T.; Do, R. K. G.; Balachandran, V. P.; D'Angelica, M. I.; Drebin, J. A.; Kingham, T. P.; Wei, A. C.; Jarnagin, W. R.; Chakraborty, J.
Article Title: Machine learning radiomics can predict early liver recurrence after resection of intrahepatic cholangiocarcinoma
Abstract: Background: Most patients recur after resection of intrahepatic cholangiocarcinoma (IHC). We studied whether machine-learning incorporating radiomics and tumor size could predict intrahepatic recurrence within 1-year. Methods: This was a retrospective analysis of patients with IHC resected between 2000 and 2017 who had evaluable computed tomography imaging. Texture features (TFs) were extracted from the liver, tumor, and future liver remnant (FLR). Random forest classification using training (70.3%) and validation cohorts (29.7%) was used to design a predictive model. Results: 138 patients were included for analysis. Patients with early recurrence had a larger tumor size (7.25 cm [IQR 5.2–8.9] vs. 5.3 cm [IQR 4.0–7.2], P = 0.011) and a higher rate of lymph node metastasis (28.6% vs. 11.6%, P = 0.041), but were not more likely to have multifocal disease (21.4% vs. 17.4%, P = 0.643). Three TFs from the tumor, FD1, FD30, and IH4 and one from the FLR, ACM15, were identified by feature selection. Incorporation of TFs and tumor size achieved the highest AUC of 0.84 (95% CI 0.73–0.95) in predicting recurrence in the validation cohort. Conclusion: This study demonstrates that radiomics and machine-learning can reliably predict patients at risk for early intrahepatic recurrence with good discrimination accuracy. © 2022 International Hepato-Pancreato-Biliary Association Inc.
Journal Title: HPB
Volume: 24
Issue: 8
ISSN: 1365-182X
Publisher: Elsevier Science, Inc.  
Date Published: 2022-08-01
Start Page: 1341
End Page: 1350
Language: English
DOI: 10.1016/j.hpb.2022.02.004
PUBMED: 35283010
PROVIDER: scopus
PMCID: PMC9355916
DOI/URL:
Notes: Article -- Export Date: 1 August 2022 -- Source: Scopus
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MSK Authors
  1. Joanne Fu-Lou Chou
    262 Chou
  2. Mithat Gonen
    885 Gonen
  3. William R Jarnagin
    741 Jarnagin
  4. Kinh Gian Do
    197 Do
  5. T Peter Kingham
    430 Kingham
  6. Linda Ma Pak
    25 Pak
  7. Jeffrey Adam Drebin
    80 Drebin
  8. Thomas Boerner
    40 Boerner
  9. Alice Chia-Chi Wei
    55 Wei
  10. Kevin Cerqueira Soares
    32 Soares
  11. Tiegong Wang
    4 Wang