Synapse - CT radiomics to predict early hepatic recurrence after resection for intrahepatic cholangiocarcinoma

CT radiomics to predict early hepatic recurrence after resection for intrahepatic cholangiocarcinoma Conference Paper

Authors:	Chakraborty, J.; Jolissaint, J. S.; Wang, T.; Soares, K. C.; Gonen, M.; Pak, L. M.; Boerner, T.; Do, R. K. G.; Balachandran, V. P.; D'Angelica, M. I.; Drebin, J. A.; Kingham, T. P.; Wei, A. C.; Jarnagin, W. R.
Editors:	Drukker, K.; Iftekharuddin, K. M.
Title:	CT radiomics to predict early hepatic recurrence after resection for intrahepatic cholangiocarcinoma
Conference Title:	Medical Imaging 2022: Image Processing
Abstract:	Intrahepatic cholangiocarcinoma (IHC) is an aggressive liver cancer with a five-year survival rate of less than 10%. Surgery is the only curative treatment. However, most patients die of disease recurrence, with more than 50% recurring within 2 years. The liver is the most common site. Recurrence at liver within a short period after surgery is common and eventually leads to death. Currently, there is no way to assess the risk of early recurrence or death in these patients. Methods to predict these risks would help physicians select the best treatment plan for individual patients; patients at high risk of recurrence could be treated early or at the time of surgery with chemotherapy or radiation. Such changes in patient management would greatly impact patients' prospects of survival. The objective of the present study is to identify preoperative computed tomography (CT)-based quantitative imaging predictors of early hepatic recurrence. Two hundred fifty four texture features were extracted from CT-tumor and future liver remnant (FLR) along with tumor size. With features selected using minimum redundancy maximum relevance method and AdaBoost classifier, we obtained an area under the receiver operating characteristic curve of 0.78 using a 3-fold cross-validation for a cohort of 139 patients with IHC. © 2022 SPIE.
Keywords:	survival rate; chemotherapy; risk assessment; computerized tomography; medical imaging; tumors; surgery; intrahepatic cholangiocarcinoma; cholangiocarcinoma; computed tomography; treatment plans; textures; patient management; adaptive boosting; radiomics; liver cancers; short periods; radiomic; early hepatic recurrence
Journal Title	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume:	12033
Conference Dates:	2022 Feb 20-March 28
Conference Location:	San Diego, CA
ISBN:	1605-7422
Publisher:	SPIE
Date Published:	2022-04-04
Start Page:	120333C
Language:	English
DOI:	10.1117/12.2612889
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85132837153&doi=10.1117%2f12.2612889&partnerID=40&md5=0ad55403193b56af590c6dc76f762b5d
Notes:	Conference Paper -- Export Date: 1 August 2022 -- Source: Scopus