Defining the impact of family history on detection of high-grade prostate cancer in a large multi-institutional cohort Journal Article
| Authors: | Clements, M. B.; Vertosick, E. A.; Guerrios-Rivera, L.; De Hoedt, A. M.; Hernandez, J.; Liss, M. A.; Leach, R. J.; Freedland, S. J.; Haese, A.; Montorsi, F.; Boorjian, S. A.; Poyet, C.; Ankerst, D. P.; Vickers, A. J. |
| Article Title: | Defining the impact of family history on detection of high-grade prostate cancer in a large multi-institutional cohort |
| Abstract: | Background: The risk of high-grade prostate cancer, given a family history of cancer, has been described in the general population, but not among men selected for prostate biopsy in an international cohort. Objective: To estimate the risk of high-grade prostate cancer on biopsy based on a family history of cancer. Design, setting, and participants: This is a multicenter study of men undergoing prostate biopsy from 2006 to 2019, including 12 sites in North America and Europe. All sites recorded first-degree prostate cancer family histories; four included more detailed data on the number of affected relatives, second-degree relatives with prostate cancer, and breast cancer family history. Outcomes measurements and statistical analysis: Multivariable logistic regressions evaluated odds of high-grade (Gleason grade group ≥2) prostate cancer. Separate models were fit for family history definitions, including first- and second-degree prostate cancer and breast cancer family histories. Results and limitations: A first-degree prostate cancer family history was available for 15 799 men, with a more detailed family history for 4617 (median age 65 yr, both cohorts). Adjusted odds of high-grade prostate cancer were 1.77 times greater (95% confidence interval [CI] 1.57−2.00, p < 0.001, risk ratio [RR] = 1.40) with first-degree prostate cancer, 1.38 (95% CI 1.07−1.77, p = 0.011, RR = 1.22) for second-degree prostate cancer, and 1.30 (95% CI 1.01−1.67, p = 0.040, RR = 1.18) for first-degree breast cancer family histories. Interaction terms revealed that the effect of a family history did not differ based on prostate-specific antigen but differed based on age. This study is limited by missing data on race and prior negative biopsy. Conclusions: Men with indications for biopsy and a family history of prostate or breast cancer can be counseled that they have a moderately increased risk of high-grade prostate cancer, independent of other risk factors. Patient summary: In a large international series of men selected for prostate biopsy, finding a high-grade prostate cancer was more likely in men with a family history of prostate or breast cancer. © 2021 European Association of Urology |
| Keywords: | human tissue; aged; major clinical study; genetics; clinical trial; nuclear magnetic resonance imaging; cancer grading; prostate specific antigen; breast cancer; cohort analysis; risk factors; pathology; breast neoplasms; risk factor; biopsy; risk; prostate cancer; gleason score; prostate-specific antigen; prostatic neoplasms; prostate; multicenter study; family history; breast tumor; prostate tumor; diagnosis; prostate biopsy; logistic regression analysis; father; neoplasm grading; first-degree relative; second-degree relative; humans; human; male; article; tertiary care center; brother; regression model; high grade prostate cancer |
| Journal Title: | European Urology |
| Volume: | 82 |
| Issue: | 2 |
| ISSN: | 0302-2838 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2022-09-01 |
| Start Page: | 163 |
| End Page: | 169 |
| Language: | English |
| DOI: | 10.1016/j.eururo.2021.12.011 |
| PUBMED: | 34980493 |
| PROVIDER: | scopus |
| PMCID: | PMC9243191 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 August 2022 -- Source: Scopus |
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