Research-relevant conditions and pathology of laboratory mice, rats, gerbils, guinea pigs, hamsters, naked mole rats, and rabbits Review
| Authors: | Cooper, T. K.; Meyerholz, D. K.; Beck, A. P.; Delaney, M. A.; Piersigilli, A.; Southard, T. L.; Brayton, C. F. |
| Review Title: | Research-relevant conditions and pathology of laboratory mice, rats, gerbils, guinea pigs, hamsters, naked mole rats, and rabbits |
| Abstract: | Animals are valuable resources in biomedical research in investigations of biological processes, disease pathogenesis, therapeutic interventions, safety, toxicity, and carcinogenicity. Interpretation of data from animals requires knowledge not only of the processes or diseases (pathophysiology) under study but also recognition of spontaneous conditions and background lesions (pathology) that can influence or confound the study results. Species, strain/stock, sex, age, anatomy, physiology, spontaneous diseases (noninfectious and infectious), and neoplasia impact experimental results and interpretation as well as animal welfare. This review and the references selected aim to provide a pathology resource for researchers, pathologists, and veterinary personnel who strive to achieve research rigor and validity and must understand the spectrum of "normal"and expected conditions to accurately identify research-relevant experimental phenotypes as well as unusual illness, pathology, or other conditions that can compromise studies involving laboratory mice, rats, gerbils, guinea pigs, hamsters, naked mole rats, and rabbits. © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the National Academies of Sciences, Engineering, and Medicine. All rights reserved. |
| Keywords: | pathogenesis; review; nonhuman; mouse; animal; animals; mice; animal tissue; animal model; pathology; age; mus musculus; bagg albino mouse; cardiovascular system; medical research; rat; carcinogenicity; herpesviridae; validity; rats; safety; anatomy; rodent; c57bl 6 mouse; urogenital system; staphylococcus aureus; toxicity; streptococcus pneumoniae; bordetella bronchiseptica; pathologist; sprague dawley rat; long evans rat; adenoviridae; sex; lewis rat; nervous system; species; poxviridae; cricetinae; communicable disease; norovirus; endocrine system; pseudomonas aeruginosa; giardia; rabbits; communicable diseases; musculoskeletal system; citrobacter rodentium; clostridium; pneumocystis; klebsiella; animal welfare; candida; respiratory system; hamster; guinea pig; polyomaviridae; salmonella enterica; wistar furth rat; corynebacterium; aspiculuris tetraptera; c3h mouse; helicobacter; orthopoxvirus; guinea pigs; encephalitozoon cuniculi; cellular, subcellular and molecular biological phenomena and functions; muromegalovirus; wistar rat; mastadenovirus; parvoviridae; reoviridae; cardiovirus; streptobacillus moniliformis; swiss james lambert mouse; buffalo rat; picornaviridae; biological phenomena; respirovirus; dahl salt sensitive rat; bordetella; clostridioides difficile; betacoronavirus; leporidae; gerbillinae; mole rats; alphapolyomavirus; b6c3f1 mouse; betapolyomavirus; biological phenomena and functions concerning the entire organism; brattleboro rat; copenhagen rat; corynebacterium kutscheri; cryptosporidium muris; dunkin hartley guinea pig; eimeria; gerbil; heterocephalus; lymphocryptovirus; mammarenavirus; mycoplasma pulmonis; osborne mendel rat; pneumovirus; sarcocystis; staphylococcus xylosus; trichophyton; trichophyton mentagrophytes; wistar kyoto rat; zucker fatty rat; mole rat |
| Journal Title: | ILAR Journal |
| Volume: | 62 |
| Issue: | 1-2 |
| ISSN: | 1084-2020 |
| Publisher: | Oxford University Press |
| Date Published: | 2021-01-01 |
| Start Page: | 77 |
| End Page: | 132 |
| Language: | English |
| DOI: | 10.1093/ilar/ilab022 |
| PUBMED: | 34979559 |
| PROVIDER: | scopus |
| PMCID: | PMC9291387 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 August 2022 -- Source: Scopus |
