Pancreaticoduodenal arterial rupture and hemoabdomen in ACI/SegHsd rats with polyarteritis nodosa Journal Article
| Authors: | Cohen, J. K.; Cai, L. Q.; Zhu, Y. S.; La Perle, K. M. D. |
| Article Title: | Pancreaticoduodenal arterial rupture and hemoabdomen in ACI/SegHsd rats with polyarteritis nodosa |
| Abstract: | Many lesions associated with aging have been well-characterized in various strains of rats. Although documented in Sprague-Dawley and spontaneously hypertensive rats, polyarteritis nodosa has not previously been reported in ACI/SegHsd rats. ACI/ SegHsd rats were maintained on high-fat (40.5%), low-fat (11.6%), and high-fat to low-fat dietary protocols to examine the correlation between dietary fat and the regulation of prostate 5α-reductase gene expression and prostate cancer. Seven rats died unexpectedly with hemoabdomen and rupture of the pancreaticoduodenal artery secondary to polyarteritis nodosa (PAN). The purpose of this study was to analyze the pathologic findings in these and the remaining ACI/SegHsd rats and to correlate the level of dietary fat with the presence of PAN, arterial rupture, and hemoabdomen. Approximately 65% of the rats had evidence of PAN by histopathology, with a 24% incidence of arterial rupture. Additional lesions noted included an 88% incidence of chronic progressive nephropathy (CPN) and a 32% incidence of cartilaginous foci in the aortic valve. We found no association between the percentage of dietary fat and incidence of PAN, CPN, or cardiac cartilage. Although arterial rupture is a known complication of polyarteritis nodosa in humans, this case series is the first to document arterial rupture and hemoabdomen in rats with PAN. Copyright 2007 by the American Association for Laboratory Animal Science. |
| Keywords: | controlled study; survival rate; histopathology; mortality; gastrointestinal hemorrhage; nonhuman; animal cell; mouse; animal; animals; mice; animal tissue; disease association; kidney disease; incidence; animal experiment; animal model; pathology; vascularization; prostate cancer; disease model; gene expression regulation; correlation analysis; species specificity; dog; dogs; rat; blood vessel; species difference; aging; rats; disease models, animal; rupture, spontaneous; macaca; sprague dawley rat; pancreas disease; steroid 5alpha reductase; fat; aorta valve; rupture; macaca fascicularis; fat intake; abdominal bleeding; arteries; peritoneal cavity; artery; dietary fats; aci seghsd rat; artery rupture; body fat; cardiac cartilage; cartilaginous tissue; chronic progressive nephropathy; pancreaticoduodenal artery; polyarteritis nodosa; rat strain; spontaneously hypertensive rat; strain identification; duodenum disease; abdominal cavity; duodenal diseases; pancreatic diseases; rats, inbred strains |
| Journal Title: | Comparative Medicine |
| Volume: | 57 |
| Issue: | 4 |
| ISSN: | 1532-0820 |
| Publisher: | American Association for Laboratory Animal Science |
| Date Published: | 2007-08-01 |
| Start Page: | 370 |
| End Page: | 376 |
| Language: | English |
| PUBMED: | 17803051 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 17 November 2011" - "CODEN: COMEF" - "Source: Scopus" |
