Skin cancer risk among testicular germ-cell cancer survivors: A systematic review and meta-analysis Review

  


Authors: Reiter, O.; Voss, V. B.; Fluss, R.; Boyce, L. M.; DeFazio, J. L.; Halpern, A. C.; Marghoob, A. A.
Review Title: Skin cancer risk among testicular germ-cell cancer survivors: A systematic review and meta-analysis
Abstract: Testicular germ-cell tumours (TGCT) are the most common cancer among young adult men. Previous studies suggested TGCT survivors have an increased risk for skin cancer. The goal of this study was to systematically review the literature and evidence regarding skin cancer risk among TGCT survivors compared with the general population. PubMed, EMBASE, Web of Science, Cochrane Databases and reference lists were included in the search. A systematic review of all comparative studies with more than 10 TGCT survivors reporting on skin cancer incidence was performed. A meta-analysis of the Standardized Incidence Rate (SIR) was calculated by pooling study-specific log-transformed estimates using the random-effects model. Risk of bias was assessed using the Newcastle–Ottawa Quality Assessment Scale. Nineteen studies that reported on 147 935 TGCT survivors were included. Pooled SIR for skin cancer and for melanoma incidence among TGCT survivors were 1.93 (95% CI 1.62–2.29, P < 0.0001) and 1.81 (95% CI 1.57–2.08, P < 0.0001), respectively. In conclusion, compared to the general population, TGCT survivors have an increased risk for developing skin cancer and melanoma. Additional long-term studies that include TGCT survivors, additional risk factors and all subtypes of skin cancer are required. © 2022 European Academy of Dermatology and Venereology.
Keywords: cancer survival; young adult; review; cancer risk; cancer patient; comparative study; follow up; cancer incidence; neoplasm; melanoma; skin neoplasms; skin cancer; risk factors; patient monitoring; information processing; reference database; risk factor; high risk patient; radiation exposure; survivor; cancer survivor; risk assessment; survivors; skin tumor; systematic review; control group; skin examination; data analysis; testis tumor; testicular neoplasms; neoplasms, germ cell and embryonal; cancer epidemiology; meta analysis; cutaneous melanoma; cancer survivors; standardized incidence ratio; adult disease; data extraction; humans; human; male; patient history of radiotherapy; germ cell cancer; patient history of chemotherapy; newcastle-ottawa scale; male genital system disease
Journal Title: Journal of the European Academy of Dermatology and Venereology
Volume: 36
Issue: 7
ISSN: 0926-9959
Publisher: Wiley Blackwell  
Date Published: 2022-07-01
Start Page: 1025
End Page: 1033
Language: English
DOI: 10.1111/jdv.17932
PUBMED: 35034398
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124519421&doi=10.1111%2fjdv.17932&partnerID=40&md5=68a90fb06962d9f01f59f06e96780e5e
Notes: Review -- Export Date: 1 July 2022 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Allan C Halpern
    396 Halpern
  2. Jennifer Defazio
    16 Defazio
  3. Ashfaq A Marghoob
    534 Marghoob
  4. Lindsay Marie Boyce
    18 Boyce
  5. Ofer Reiter Agar
    15 Reiter Agar
Related MSK Work