Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort Journal Article


Authors: Kurt, B. A.; Nolan, V. G.; Ness, K. K.; Neglia, J. P.; Tersak, J. M.; Hudson, M. M.; Armstrong, G. T.; Hutchinson, R. J.; Leisenring, W. M.; Oeffinger, K. C.; Robison, L. L.; Arora, M.
Article Title: Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort
Abstract: Background: Chronic health conditions are common among long-term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause-specific hospitalization rates among survivors of childhood cancer and compare rates to the U.S. population. Procedure: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort of 5+ year survivors of childhood malignancies treated at 26 participating centers. Self-reported hospitalizations from 10,366 survivors (diagnosed 1970-1986) were compared to U.S. population rates using age- and sex-stratified standardized incidence ratios (SIRs). Reasons for hospitalization were evaluated and associations between demographic, cancer and treatment-related risk factors with hospitalization were investigated. Results: Survivors were, on average, 20.9 years from cancer diagnosis (SD: 4.6, range: 13-32) and 28.6 years of age (SD: 7.7, range: 13-51). Survivor hospitalization rates were 1.6 times the U.S. population (95% CI: 1.6; 1.7). Increased hospitalization rates were noted irrespective of gender, age at follow-up and cancer diagnosis, with highest SIRs noted among male (SIR=2.6, 95% CI: 2.2; 3.0) and female (SIR=2.7, 95% CI: 2.4; 3.1) survivors aged 45-54. Female gender, an existing chronic health condition and/or a second neoplasm, and prior treatment with radiation were associated with an increased risk of non-obstetrical hospitalization. Conclusions: Survivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment-related complications as this population ages. © 2011 Wiley Periodicals, Inc.
Keywords: childhood cancer; cancer survivor; hospitalization
Journal Title: Pediatric Blood and Cancer
Volume: 59
Issue: 1
ISSN: 1545-5009
Publisher: Wiley Periodicals, Inc  
Date Published: 2012-07-15
Start Page: 126
End Page: 132
Language: English
DOI: 10.1002/pbc.24017
PROVIDER: scopus
PMCID: PMC3359936
PUBMED: 22180128
DOI/URL:
Notes: --- - "Export Date: 4 June 2012" - "CODEN: PBCEA" - "Source: Scopus"
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  1. Kevin Oeffinger
    286 Oeffinger