Regional CAR T cell therapy: An ignition key for systemic immunity in solid tumors Editorial
| Authors: | Cherkassky, L.; Hou, Z.; Amador-Molina, A.; Adusumilli, P. S. |
| Title: | Regional CAR T cell therapy: An ignition key for systemic immunity in solid tumors |
| Abstract: | The success of chimeric antigen receptor (CAR) T cell therapy in solid tumors, unlike in hematologic malignancies, is limited by inadequate tumor infiltration and T cell dysfunction and exhaustion. Regional delivery of CAR T cells in patients with solid tumors is safe and feasible; promotes infiltration, proliferation, and trafficking; and ignites functionally persisting systemic immunity. © 2022 Elsevier Inc. |
| Keywords: | genetics; neoplasm; neoplasms; t lymphocyte; t-lymphocytes; tumor antigen; antigens, neoplasm; receptors, antigen, t-cell; adoptive cell therapy; adoptive immunotherapy; immunotherapy, adoptive; lymphocyte antigen receptor; tumor microenvironment; humans; human; chimeric antigen receptor (car) t cells; receptors, chimeric antigen; regional therapies; solid tumors cell therapy |
| Journal Title: | Cancer Cell |
| Volume: | 40 |
| Issue: | 6 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2022-06-13 |
| Start Page: | 569 |
| End Page: | 574 |
| Language: | English |
| DOI: | 10.1016/j.ccell.2022.04.006 |
| PUBMED: | 35487216 |
| PROVIDER: | scopus |
| PMCID: | PMC9197990 |
| DOI/URL: | |
| Notes: | Note -- Export Date: 1 July 2022 -- Source: Scopus |
