Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors Review

   


Authors: Kimura, Y.; Ghosn, M.; Cheema, W.; Adusumilli, P. S.; Solomon, S. B.; Srimathveeralli, G.
Review Title: Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors
Abstract: Adoptive cell therapy with chimeric antigen receptors (CAR) T cells has proven effective for hematologic malignancies, but success in solid tumors has been impeded by poor intratumoral infiltration, exhaustion of effector cells from antigen burden, and an immunosuppressive tumor microenvironment. Results from recent clinical trials and preclinical studies lend promising evidence of locoregional approaches for CAR T cell delivery, priming the tumor microenvironment, and performing adjuvant therapies that sustain T cell activity. Interventional oncology is a subspeciality of interventional radiology where imaging guidance is used to perform percutaneous and catheter-directed procedures for localized, non-surgical therapy or interrogation of solid tumors. Interventional oncology provides unique synergies with immunotherapy, which has been well-studied to improve treatment efficacy while reducing toxicities associated with systemic treatment. Besides aiding in CAR T cell delivery, priming, or the stimulation of the tumor microenvironment to promote effector survival and function, interventional oncology can also aid in the monitoring of treatment response through selective, multiplex tumor sampling and catheter-based venous sampling. This review presents an overview of interventional oncology, its various procedures, and its potential for advancing CAR T cell immunotherapy of solid tumors. © 2022 The Authors
Keywords: interventional radiology; embolization; interventional oncology; percutaneous ablation; image guided biopsy; car t cell therapy; venous sampling; intraarterial drug delivery; locoregional cell delivery
Journal Title: Molecular Therapy - Oncolytics
Volume: 24
ISSN: 2372-7705
Publisher: Cell Press  
Date Published: 2022-03-17
Start Page: 194
End Page: 204
Language: English
DOI: 10.1016/j.omto.2021.12.018
PROVIDER: scopus
PMCID: PMC8752905
PUBMED: 35036524
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122517727&doi=10.1016%2fj.omto.2021.12.018&partnerID=40&md5=e8c2681d00427290ef8fa08f288c7e6b
Notes: Review -- Export Date: 1 February 2022 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Stephen Solomon
    422 Solomon
  2. Prasad S Adusumilli
    496 Adusumilli
  3. Waseem Cheema
    9 Cheema
  4. Mario Ghosn
    15 Ghosn
Related MSK Work