Cefiderocol: A new cephalosporin stratagem against multidrug-resistant gram-negative bacteria Review

  


Authors: Ong'uti, S.; Czech, M.; Robilotti, E.; Holubar, M.
Review Title: Cefiderocol: A new cephalosporin stratagem against multidrug-resistant gram-negative bacteria
Abstract: Cefiderocol is a novel injectable siderophore cephalosporin that hijacks the bacterial iron transport machinery to facilitate cell entry and achieve high periplasmic concentrations. It has broad in vitro activity against gram-negative bacteria, including multidrug-resistant (MDR) organisms such as carbapenem-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and Acinetobacter baumannii. It was approved by the US Food and Drug Administration for the treatment of complicated urinary tract infections and nosocomial pneumonia based on clinical trials that demonstrated noninferiority to comparators. In this review, we summarize the available in vitro and clinical data, including recent evidence from 2 phase 3 clinical trials (APEKS-NP and CREDIBLE-CR), and discuss the place of cefiderocol in the clinician's armamentarium against MDR gram-negative infections. © 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
Keywords: antiinfective agent; anti-bacterial agents; multidrug resistance; drug resistance, multiple, bacterial; gram-negative bacteria; gram-negative bacterial infections; cephalosporins; cephalosporin derivative; gram negative infection; gram negative bacterium; microbial sensitivity tests; carbapenem derivative; humans; human; microbial sensitivity test; carbapenems; carbapenem resistant enterobacterales; cefiderocol; extended spectrum beta; gram; lactamase producing (esbl); multidrug resistant; negative bacteria
Journal Title: Clinical Infectious Diseases
Volume: 74
Issue: 7
ISSN: 1058-4838
Publisher: Oxford University Press  
Date Published: 2022-04-01
Start Page: 1303
End Page: 1312
Language: English
DOI: 10.1093/cid/ciab757
PUBMED: 34492098
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128487348&doi=10.1093%2fcid%2fciab757&partnerID=40&md5=58fe50b17de81ed14e4c13b3b2a79f47
Notes: Review -- Export Date: 2 May 2022 -- Source: Scopus
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MSK Authors
  1. Elizabeth Victoria Robilotti
    36 Robilotti
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