Harnessing radiation effects on the immune system: Balancing acts Review
| Authors: | Mathieu, M.; Budhu, S.; Khan, A.; Haimovitz-Friedman, A. |
| Review Title: | Harnessing radiation effects on the immune system: Balancing acts |
| Abstract: | The potential of radiotherapy (RT) to induce immune recognition of cancer cells is a growing topic of research. It has been suggested that partial volume irradiation used in GRID therapy/Lattice RT, a type of RT in which radiation does not cover the entire tumor intentionally but rather is spatially fractionated, sometimes induces an immune response. The therapeutic benefits of RT may not be limited solely to the targeted volume, but also present systemic antitumor effects, called the abscopal effect. The next challenge of RT now is to balance and control this immune response in patients. Here, we review what is known about the impact of RT on the innate and adaptive immune response. © 2021 Begell House Inc.. All rights reserved. |
| Keywords: | radiation; inflammation; immunotherapy; tumor microenvironment |
| Journal Title: | Onco Therapeutics |
| Volume: | 8 |
| Issue: | 2 |
| ISSN: | 2694-4642 |
| Publisher: | Begell House, Inc |
| Date Published: | 2021-01-01 |
| Start Page: | 37 |
| End Page: | 50 |
| Language: | English |
| DOI: | 10.1615/ForumImmunDisTher.2021041475 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 May 2022 -- Source: Scopus |
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