Altered regional homogeneity in patients with ovarian cancer treated with chemotherapy: A resting state fMRI study Journal Article
| Authors: | Vachha, B. A.; Gohel, S.; Root, J. C.; Kryza-Lacombe, M.; Hensley, M. L.; Correa, D. D. |
| Article Title: | Altered regional homogeneity in patients with ovarian cancer treated with chemotherapy: A resting state fMRI study |
| Abstract: | Many patients treated with chemotherapy for non-central nervous system (CNS) cancers experience cognitive dysfunction. However, few studies have investigated treatment-related neurotoxicity in women with ovarian cancer. The goal of this study was to assess regional brain function in patients with ovarian cancer after first-line chemotherapy. Seventeen patients with ovarian cancer and seventeen healthy controls matched for gender, age and education participated in the study. The patients were evaluated 1–4 months after completion of first line taxane/platinum chemotherapy. All participants underwent resting state functional MRI (rsfMRI) and regional homogeneity (ReHo) indices were calculated. The results showed that patients had significantly decreased average ReHo values in the left middle frontal gyrus, medial prefrontal cortex, and right superior parietal lobule, compared to healthy controls. This is the first rsfMRI study showing ReHo alterations in frontal and parietal regions in patients with ovarian cancer treated with first-line chemotherapy. The findings are overall congruent with prior studies in non-CNS cancer populations and provide supporting evidence for the prevailing notion that frontal areas are particularly vulnerable to the adverse effects of chemotherapy. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | chemotherapy; nuclear magnetic resonance imaging; magnetic resonance imaging; ovarian cancer; ovarian neoplasms; diagnostic imaging; brain; ovary tumor; cognitive; frontal lobe; brain mapping; procedures; humans; human; female; resting-state fmri; regional homogeneity |
| Journal Title: | Brain Imaging and Behavior |
| Volume: | 16 |
| Issue: | 2 |
| ISSN: | 1931-7557 |
| Publisher: | Springer |
| Date Published: | 2022-04-01 |
| Start Page: | 539 |
| End Page: | 546 |
| Language: | English |
| DOI: | 10.1007/s11682-021-00525-5 |
| PUBMED: | 34409561 |
| PROVIDER: | scopus |
| PMCID: | PMC8854444 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 25 April 2022 -- Source: Scopus |
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