Regulation of the alternative neural transcriptome by ELAV/Hu RNA binding proteins Review

Authors: Wei, L.; Lai, E. C.
Review Title: Regulation of the alternative neural transcriptome by ELAV/Hu RNA binding proteins
Abstract: The process of alternative polyadenylation (APA) generates multiple 3' UTR isoforms for a given locus, which can alter regulatory capacity and on occasion change coding potential. APA was initially characterized for a few genes, but in the past decade, has been found to be the rule for metazoan genes. While numerous differences in APA profiles have been catalogued across genetic conditions, perturbations, and diseases, our knowledge of APA mechanisms and biology is far from complete. In this review, we highlight recent findings regarding the role of the conserved ELAV/Hu family of RNA binding proteins (RBPs) in generating the broad landscape of lengthened 3' UTRs that is characteristic of neurons. We relate this to their established roles in alternative splicing, and summarize ongoing directions that will further elucidate the molecular strategies for neural APA, the in vivo functions of ELAV/Hu RBPs, and the phenotypic consequences of these regulatory paradigms in neurons. Copyright © 2022 Wei and Lai.
Keywords: nervous system; neuron; hu proteins; elav proteins; alternative polyadenylation (apa); alternative splicing (as); rna binding protein (rbp)
Journal Title: Frontiers in Genetics
Volume: 13
ISSN: 1664-8021
Publisher: Frontiers Media S.A.  
Date Published: 2022-02-23
Start Page: 848626
Language: English
DOI: 10.3389/fgene.2022.848626
PROVIDER: scopus
PMCID: PMC8904962
PUBMED: 35281806
Notes: Review -- Export Date: 1 April 2022 -- Source: Scopus
Citation Impact
MSK Authors
  1. Eric C Lai
    141 Lai