Synapse - Atypical pathogens presenting with pulmonary consolidations detected by cell-free DNA next-generation sequencing in patients with hematologic malignancies

Atypical pathogens presenting with pulmonary consolidations detected by cell-free DNA next-generation sequencing in patients with hematologic malignancies Review

Authors:	Caldararo, M.; Algazaq, J.; Schmidt, E.; Joanow, A.; Mariano, A.; Predmore, J.; Politikos, I.; Cho, C.; Stein, E. M.; Wen, X.; Travis, W. D.; Raible, K.; Cintron, M.; Babady, N. E.; Papanicolaou, G.; Lee, Y. J.
Review Title:	Atypical pathogens presenting with pulmonary consolidations detected by cell-free DNA next-generation sequencing in patients with hematologic malignancies
Abstract:	Identification of pathogens with pulmonary presentation in patients with hematologic malignancies may be challenging because of diagnostic difficulty related to the underlying malignancy and limitations of conventional microbiologic methods. Herein, we present a case series of 3 patients with pulmonary consolidations due to Legionella bozemanae necrotizing pneumonia, Pneumocystis jirovecii pneumonia, and disseminated Scedosporium infection, who were diagnosed by microbial cell-free DNA next-generation sequencing. We observed that this new sequencing modality was in agreement with criterion standard diagnostics, posing a potential solution to the problem of limited capability in diagnosing infections in hematological malignancy patients.
Keywords:	complications; karius; cell-free dna next-generation sequencing; atypical pathogen
Journal Title:	Infectious Diseases in Clinical Practice
Volume:	30
Issue:	2
ISSN:	1056-9103
Publisher:	Lippincott Williams & Wilkins
Date Published:	2022-03-01
Start Page:	e1101
Language:	English
ACCESSION:	WOS:000750436000001
DOI:	10.1097/ipc.0000000000001101
PROVIDER:	Clarivate Analytics Web of Science
PROVIDER:	wos
PMCID:	PMC9109825
PUBMED:	35586753
Notes:	Article -- e1101 -- Source: Wos