Simultaneous resection for synchronous colorectal cancer liver metastases: A feasibility clinical trial Journal Article
| Authors: | Serrano, P. E.; Parpia, S.; Karanicolas, P.; Gallinger, S.; Wei, A. C.; Simunovic, M.; Bhandari, M.; Levine, M. |
| Article Title: | Simultaneous resection for synchronous colorectal cancer liver metastases: A feasibility clinical trial |
| Abstract: | Background and Objectives: We tested the feasibility of a simultaneous resection clinical trial in patients with synchronous colorectal cancer liver metastases to obtain the necessary information to plan a randomized trial. Methods: Multicenter feasibility single-arm trial enrolling patients with synchronous colorectal cancer liver metastases eligible for simultaneous resection. Prespecified criteria for feasibility were: proportion of eligible patients enrolled ≥66%, and the proportion of enrolled patients who completed simultaneous resection ≥75%. The prespecified 90-day major postoperative complication rate was 30%. Results: Of 61 eligible patients from February 2017 to August 2019, 41 were enrolled (67%; 95% confidence interval [CI], 55%–78%), 32 underwent simultaneous resection (78%; 95% CI, 63%–88%). Four patients were not enrolled due to the surgeon's preference, three were due to the complexity of resection (right hepatectomy and low anterior resection). Intraoperative complications during liver resection (n = 4) and progression of disease (n = 4) were the main reasons for not undergoing simultaneous resection. The 90-day incidence of major complications was 41% (95% CI, 16%–58%) and the 90-day postoperative mortality was 6% (95% CI, 1.7%–20%). Conclusion: According to prespecified criteria, enrolling patients with synchronous colorectal cancer liver metastases to a trial of simultaneous resection is feasible; however, it is associated with higher than anticipated 90-day postoperative complications. © 2021 Wiley Periodicals LLC. |
| Keywords: | adult; controlled study; aged; middle aged; cancer surgery; major clinical study; clinical trial; cancer growth; liver neoplasms; cancer radiotherapy; follow up; follow-up studies; antineoplastic agent; laparoscopy; prospective study; prospective studies; colorectal cancer; pathology; postoperative complication; colorectal neoplasms; liver metastasis; feasibility study; pilot study; feasibility studies; multicenter study; colorectal tumor; liver tumor; liver resection; surgical mortality; hepatectomy; postoperative hemorrhage; hemicolectomy; canada; multiple cancer; neoplasms, multiple primary; colorectal liver metastases; peroperative complication; clinical outcome; social interaction; wedge resection; preoperative chemotherapy; feasibility; procedures; synchronous metastases; palliative chemotherapy; humans; prognosis; human; male; female; article; hemihepatectomy; simultaneous resection |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 125 |
| Issue: | 4 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2022-03-15 |
| Start Page: | 671 |
| End Page: | 677 |
| Language: | English |
| DOI: | 10.1002/jso.26764 |
| PUBMED: | 34878649 |
| PROVIDER: | scopus |
| PMCID: | PMC9896571 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2022 -- Source: Scopus |
