Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events Journal Article


Authors: O’Brien, C. E.; Zhai, B.; Ola, M.; Bergin, S. A.; Cinnéide, E. Ó; O’Connor, Í; Rolling, T.; Miranda, E.; Esther Babady, N.; Hohl, T. M.; Butler, G.
Article Title: Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events
Abstract: Candida metapsilosis is a member of the Candida parapsilosis species complex, a group of opportunistic human pathogens. Of all the members of this complex, C. metapsilosis is the least virulent, and accounts for a small proportion of invasive Candida infections. Previous studies established that all C. metapsilosis isolates are hybrids, originating from a single hybridization event between two lineages, parent A and parent B. Here, we use MinION and Illumina sequencing to characterize a C. metapsilosis isolate that originated from a separate hybridization. One of the parents of the new isolate is very closely related to parent A. However, the other parent (parent C) is not the same as parent B. Unlike C. metapsilosis AB isolates, the C. metapsilosis AC isolate has not undergone introgression at the mating type-like locus. In addition, the A and C haplotypes are not fully collinear. The C. metapsilosis AC isolate has undergone loss of heterozygosity with a preference for haplotype A, indicating that this isolate is in the early stages of genome stabilization. © The Author(s) 2021.
Keywords: nonhuman; haplotype; genomics; heterozygosity loss; hybridization; candida; loh; human; article; introgression; candida metapsilosis; illumina sequencing; mating type-like loci; mating type
Journal Title: G3: Genes, Genomes, Genetics
Volume: 12
Issue: 1
ISSN: 2160-1836
Publisher: Genetics Society of America  
Date Published: 2022-01-01
Start Page: jkab367
Language: English
DOI: 10.1093/g3journal/jkab367
PUBMED: 34791169
PROVIDER: scopus
PMCID: PMC8727981
DOI/URL:
Notes: Article -- Export Date: 1 March 2022 -- Source: Scopus
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MSK Authors
  1. Ngolela Esther Babady
    174 Babady
  2. Tobias Martin Hohl
    105 Hohl
  3. Edwin Miranda
    11 Miranda
  4. Bing   Zhai
    16 Zhai
  5. Thierry Rolling
    12 Rolling