Pathogenesis of triple-negative breast cancer Review


Authors: Derakhshan, F.; Reis-Filho, J. S.
Review Title: Pathogenesis of triple-negative breast cancer
Abstract: Triple-negative breast cancer (TNBC) encompasses a heterogeneous group of fundamentally different diseases with different histologic, genomic, and immunologic profiles, which are aggregated under this term because of their lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. Massively parallel sequencing and other omics technologies have demonstrated the level of heterogeneity in TNBCs and shed light into the pathogenesis of this therapeutically challenging entity in breast cancer. In this review, we discuss the histologic and molecular classifications of TNBC, the genomic alterations these different tumor types harbor, and the potential impact of these alterations on the pathogenesis of these tumors. We also explore the role of the tumor microenvironment in the biology of TNBCs and its potential impact on therapeutic response. Dissecting the biology and understanding the therapeutic dependencies of each TNBC subtype will be essential to delivering on the promise of precision medicine for patients with triple-negative disease. Copyright © 2022 by Annual Reviews. All rights reserved.
Keywords: breast cancer; genomics; molecular pathology; basal-like; subtypes; triple-negative
Journal Title: Annual Review of Pathology: Mechanisms of Disease
Volume: 17
ISSN: 1553-4006
Publisher: Annual Reviews  
Date Published: 2022-01-01
Start Page: 181
End Page: 204
Language: English
DOI: 10.1146/annurev-pathol-042420-093238
PUBMED: 35073169
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 1 March 2022 -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors