The spectrum of triple-negative breast disease: High- and low-grade lesions Journal Article

   


Authors: Geyer, F. C.; Pareja, F.; Weigelt, B.; Rakha, E.; Ellis, I. O.; Schnitt, S. J.; Reis-Filho, J. S.
Article Title: The spectrum of triple-negative breast disease: High- and low-grade lesions
Abstract: Triple-negative breast cancer is viewed clinically as an aggressive subgroup of breast cancer. In fact, most triple-negative breast cancers are poor-prognosis tumors with a complex genomic landscape. However, triple-negative disease is vastly heterogeneous, encompassing multiple entities with marked genetic, transcriptional, histologic, and clinical differences, with neoplasms in this group ranging from low to high grade. Among the less common low-grade triple-negative lesions, two large subgroups, both with a rather indolent behavior, can be distinguished: a low-grade triple-negative breast neoplasia family, which includes nonobligate precursors of triple-negative breast cancer, and, despite being low-grade, harbors the complex genomic landscape of usual triple-negative breast cancer, and the salivary gland-like tumors of the breast, lacking all the cardinal molecular features of conventional triple-negative breast cancer and underpinned by specific fusion genes or hotspot mutations, which may be of diagnostic and possibly therapeutic utility. Progression to high-grade triple-negative breast cancer likely occurs in both subgroups but at different rates. In this review, we describe the heterogeneity of triple-negative disease, focusing on the histologic and molecular features of the low-grade lesions. Recognition that triple-negative breast cancer is an operational term and that triple-negative disease is heterogeneous and includes low-grade forms driven by distinct sets of genetic alterations is germane to the successful implementation of precision medicine. © 2017 American Society for Investigative Pathology
Keywords: genetics; cancer grading; evolution; cell differentiation; pathology; triple negative breast cancer; biological evolution; neoplasm grading; humans; human; female; triple negative breast neoplasms
Journal Title: American Journal of Pathology
Volume: 187
Issue: 10
ISSN: 0002-9440
Publisher: Elsevier Science, Inc.  
Date Published: 2017-10-01
Start Page: 2139
End Page: 2151
Language: English
DOI: 10.1016/j.ajpath.2017.03.016
PUBMED: 28736315
PROVIDER: scopus
PMCID: PMC5809519
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030749517&doi=10.1016%2fj.ajpath.2017.03.016&partnerID=40&md5=616c922f3afa43e38edf9cd6f041dd68
Notes: Review -- Export Date: 2 November 2017 -- Source: Scopus
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MSK Authors
  1. Britta Weigelt
    632 Weigelt
  2. Jorge Sergio Reis-Filho
    639 Reis-Filho
  3. Fresia Gilda Pareja Zea
    216 Pareja Zea
  4. Felipe Correa Geyer
    107 Correa Geyer
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