Extramedullary hematopoiesis in myeloproliferative neoplasms: Pathophysiology and treatment strategies Review

  


Authors: Chernak, B. J.; Rampal, R. K.
Review Title: Extramedullary hematopoiesis in myeloproliferative neoplasms: Pathophysiology and treatment strategies
Abstract: Extramedullary hematopoiesis (EMH) is often a physiologic response to ineffective marrow production of hematologic cells. While this can be found incidentally in various physiologic and pathophysiologic states, the myeloproliferative neoplasms (MPNs) are some of the most common underlying conditions found in patients with EMH. Although this process can assist with hematologic production in defective states, the burden of EMH can lead to symptomatic discomfort and mechanical obstructive complications, most commonly in the spleen and liver. Here we describe the pathophysiology of EMH, treatment options, including medical, surgical and radiation-based approaches. © 2021 Elsevier Inc.
Keywords: myelofibrosis; hepatomegaly; splenomegaly; extramedullary hematopoiesis
Journal Title: International Review of Cell and Molecular Biology
Volume: 365
ISSN: 1937-6448
Publisher: Elsevier Inc.  
Date Published: 2021-01-01
Start Page: 97
End Page: 116
Language: English
DOI: 10.1016/bs.ircmb.2021.07.002
PUBMED: 34756246
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116121293&doi=10.1016%2fbs.ircmb.2021.07.002&partnerID=40&md5=108c57aa41d6b94e0e3ec8b942423df5
Notes: Book Chapter 3 in Bartalucci N, Galluzzi L, eds. "Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part A" (ISBN: 978-0-323-89939-0) -- Export Date: 1 February 2022 -- Source: Scopus
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MSK Authors
  1. Raajit Kumar Rampal
    339 Rampal
  2. Brian J Chernak
    3 Chernak
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