Molecular imaging in nuclear cardiology Journal Article
| Authors: | Strauss, H. W.; Grewal, R. K.; Pandit-Taskar, N. |
| Article Title: | Molecular imaging in nuclear cardiology |
| Abstract: | State-of-the-art techniques have been used to measure key aspects of cardiovascular pathophysiology from the birth of radionuclide cardiovascular imaging. However, during the last 30 years, there have been few innovative imaging advances to further our understanding of the complex physiologic processes. Molecular imaging now offers an array of tools to develop advanced diagnostic approaches and therapies for patients with coronary artery disease and heart failure. For example, the enhanced understanding of the pathophysiology of atheroma makes it possible to identify vulnerable plaque based on its metabolic signature or the presence of excessive apoptosis. Because the metabolic and apoptotic signals are large, it is likely that even small lesions will be visible. Of the many approaches that are being developed, 2 tracers appear most likely to be tested in the near future: (1) [ 18F]-fluorodeoxyglucose, to determine macrophage metabolism; and (2) radiolabeled annexin, to measure apoptosis of the inflammatory cells. Using existing techniques such as perfusion imaging, appropriate patients can be selected for treatment with novel therapies, such as stem cell transplantation or vascular gene therapy. Using positron tomography in place of single photon imaging adds the capability for the measurement of absolute perfusion and perfusion reserve to the information on regional perfusion. Flow reserve detects global decreases in perfusion and refines the determination of lesion severity available from perfusion imaging. © 2004 Elsevier Inc. All rights reserved. |
| Keywords: | review; pathophysiology; positron emission tomography; technetium 99m; radiopharmaceuticals; apoptosis; heart disease; diagnostic approach route; stem cell transplantation; molecular imaging; diagnostic imaging; disease severity; immunoglobulin g; iodine 125; isotope labeling; heart failure; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; gene therapy; regional perfusion; nuclear medicine; radioisotope; macrophage; single photon emission computer tomography; indium 111; atheroma; cell metabolism; coronary artery disease; coronary vessels; heart; monocyte chemotactic protein 1; myocardium; tomography, emission-computed; perfusion; cardiology; coronary artery blood flow; high density lipoprotein; low density lipoprotein; arteriosclerosis; annexin; peptide hormone; humans; human; endothelin derivative; monocyte chemotactic protein; nuclear cardiology; annexins |
| Journal Title: | Seminars in Nuclear Medicine |
| Volume: | 34 |
| Issue: | 1 |
| ISSN: | 0001-2998 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-01-01 |
| Start Page: | 47 |
| End Page: | 55 |
| Language: | English |
| DOI: | 10.1053/j.semnuclmed.2003.09.006 |
| PROVIDER: | scopus |
| PUBMED: | 14735458 |
| DOI/URL: | |
| Notes: | Semin. Nucl. Med. -- Cited By (since 1996):22 -- Export Date: 16 June 2014 -- CODEN: SMNMA -- Source: Scopus |
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