Chaphamaparvovirus antigen and nucleic acids are not detected in kidney tissues from cats with chronic renal disease or immunocompromised cats Journal Article
| Authors: | Michel, A. O.; Donovan, T. A.; Roediger, B.; Lee, Q.; Jolly, C. J.; Monette, S. |
| Article Title: | Chaphamaparvovirus antigen and nucleic acids are not detected in kidney tissues from cats with chronic renal disease or immunocompromised cats |
| Abstract: | Chronic kidney disease (CKD) is a common cause of morbidity and mortality in domestic cats, but the cause is still largely elusive. While some viruses have been associated with this disease, none have been definitively implicated as causative. Recently, Rodent chaphamaparvovirus 1 was recognized as the cause of murine inclusion body nephropathy, a disease reported for over 40 years in laboratory mice. A novel virus belonging to the same genus, Carnivore chaphamaparvovirus 2, was recently identified in the feces of cats with diarrhea. The goal of this study was to investigate the possible role of chaphamaparvoviruses including members of Rodent chaphamaparvovirus 1 and Carnivore chaphamaparvovirus 2 in the development of feline CKD. The presence of these viruses was retrospectively investigated in formalin-fixed paraffin-embedded feline kidney samples using polymerase chain reaction, in situ hybridization, and immunohistochemistry. Cats were divided into 3 groups: normal (N = 24), CKD (N = 26), and immunocompromised (N = 25). None of the kidney tissues from any of the 75 cats revealed the presence of chaphamaparvovirus DNA, RNA, or antigen. We conclude that viruses belonging to the chaphamaparvovirus genus are unlikely to contribute to the occurrence of feline CKD. © The Author(s) 2021. |
| Keywords: | immunohistochemistry; controlled study; unclassified drug; nonhuman; polymerase chain reaction; animal tissue; animal experiment; animal model; inflammation; creatinine; histology; fibrosis; in situ hybridization; chronic kidney disease; virus rna; cat; cats; virus antigen; tissue microarray; autopsy; dna extraction; chronic kidney failure; immunocompromised patient; nucleic acid; urinary; virus dna; urea; viral; immune status; cryptococcosis; uremia; article; kidney tissue; chaphamaparvovirus; chaphamaparvovirus antigen |
| Journal Title: | Veterinary Pathology |
| Volume: | 59 |
| Issue: | 1 |
| ISSN: | 0300-9858 |
| Publisher: | Sage Publications |
| Date Published: | 2022-01-01 |
| Start Page: | 120 |
| End Page: | 126 |
| Language: | English |
| DOI: | 10.1177/03009858211045439 |
| PUBMED: | 34601998 |
| PROVIDER: | scopus |
| PMCID: | PMC9393070 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2022 -- Source: Scopus |
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