Registry-based randomized clinical trials in surgery: Working with ACS-NSQIP and the AHPBA to conduct pragmatic trials Review

  


Authors: Ecker, B. L.; Brajcich, B. C.; Ellis, R. J.; Ko, C. Y.; D'Angelica, M. I.
Review Title: Registry-based randomized clinical trials in surgery: Working with ACS-NSQIP and the AHPBA to conduct pragmatic trials
Abstract: Randomized controlled trials (RCTs) represent the gold standard for evidence in clinical medicine because of their ability to account for the effects of unmeasured confounders and selection bias by indication. However, their complexity and immense costs limit their application, and thus the availability of high-quality data to guide clinical care. Registry-based RCTs are a type of pragmatic trial that leverages existing registries as a platform for data collection, providing a low-cost alternative for randomized studies. Herein, we describe the tenets of registry RCTs and the development of the first AHPBA/ACS-NSQIP-based registry trial. © 2021 Wiley Periodicals LLC
Keywords: controlled study; randomized controlled trial; randomized controlled trials; human; article; pragmatic trial; pragmatic clinical trial; registry-based trials; surgical registry; surgical research methods; surgery registry
Journal Title: Journal of Surgical Oncology
Volume: 125
Issue: 1
ISSN: 0022-4790
Publisher: Wiley Blackwell  
Date Published: 2022-01-01
Start Page: 89
End Page: 92
Language: English
DOI: 10.1002/jso.26742
PROVIDER: scopus
PUBMED: 34897710
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120983447&doi=10.1002%2fjso.26742&partnerID=40&md5=62275279e0fc65773a42bbcf8c49d95d
Notes: Article -- Export Date: 3 January 2022 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Michael D'Angelica
    777 D'Angelica
  2. Brett Logan Ecker
    9 Ecker
  3. Ryan Joseph Ellis
    10 Ellis
Related MSK Work